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Alemtuzumab

(Synonyms: Campath-IH)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Alemtuzumab (Campath-IH) is a humanized monoclonal antibody against CD52. Alemtuzumab does not cross-react with murine CD52. Alemtuzumab selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes. Alemtuzumab is capable of complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC), as well as induction of apoptosis. Alemtuzumab has the potential for B-cell chronic lymphocytic leukaemia research.

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  • Pureté : 99.719%
  • CAS No.: 216503-57-0
  • Masse moléculaire:146.06 kDa
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  • Experimental Validation Results for Alemtuzumab
  • Experimental Validation Results for Alemtuzumab
  • Experimental Validation Results for Alemtuzumab
  • Alemtuzumab Chemical Structure
    Alemtuzumab Chemical Structure
CAS No.: 216503-57-0
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometry analysis of PBMC cells labelling CD52 with Alemtuzumab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).

  • 1/16

    Immobilized CD52 Protein, Human (His, HY-P72123) can bind Alemtuzumab. The EC50 for this effect is 1.1 ng/mL.

  • Alemtuzumab Chemical Structure
    1/16
  • Alemtuzumab
  • Flow cytometry analysis of PBMC cells labelling CD52 with Alemtuzumab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
  • Immobilized CD52 Protein, Human (His, HY-P72123) can bind Alemtuzumab. The EC50 for this effect is 1.1 ng/mL.