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Cat. No.: HY-149983

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Antibacterial agent 141

Antibacterial agent 141 (Compound B14) has antibacterial activity against four plant pathogens Xoo, Xac, Psa and Cmm, with an EC₅₀ value of 1.28 μM. Antibacterial agent 141 can inhibit the formation of cell membrane and change cell permeability.

For research use only. We do not sell to patients.

CAS No.: 2930013-56-0
Formula: C₂₃H₂₇ClN₂O₃
Molecular Weight:414.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Antibacterial agent 141 Chemical Structure

CAS No.: 2930013-56-0

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

Antibacterial agent 141 significantly induces cell membrane rupture in Xoo bacteria^[1].
Antibacterial agent 141 increases bacterial membrane permeability in a concentration-dependent manner in Xoo bacteria^[1].
Antibacterial agent 141 damages the cell membrane surface in Xoo bacteria^[1].
Antibacterial agent 141 (3.2, 6.4 μM) significantly reduces the expression of ACC, ACP and Fab family genes in Xoo bacteria^[1].
Antibacterial agent 141 significantly suppresses the formation of Xoo biofilm with the increase of concentration^[1].
Antibacterial agent 141 is low toxic to HepG2 and HK-2 cell^[1].
Antibacterial agent 141 (0.64-5.12 μM; 3-30 h) significantly inhibits the growth of Xoo bacteria^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR

Cell Line:

Xoo bacteria
Concentration:

3.2, 6.4 μM
Incubation Time:
Result:

Significantly reduced the expression of ACC, ACP and Fab family genes in Xoo bacteria.

Cell Viability Assay

Cell Line:

Xoo bacteria
Concentration:

0.64, 1.28, 2.56, 5.12 μM
Incubation Time:

3, 6, 9, 12, 15, 18, 21, 24, 27, 30 h
Result:

Had a slight inhibitory effect on bacterial growth with the concentration of 0.64, 1.28, 2.56 μM.
Inhibited the growth of bacteria more obviously when the drug concentration reached 5.12 μM.

In Vivo

Antibacterial agent 141 (200 μg/mL; 7 days; single dose) is 4.64% and 43.33% of curative and protective activity toward bacterial blight, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2930013-56-0
Molecular Weight 414.93
Formula C₂₃H₂₇ClN₂O₃
SMILES

O=C1CC2(OC3=CC=C(C=C13)Cl)CCN(CC2)CC(CNCC4=CC=CC=C4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu SS, et al. Novel spiro[chromanone-2,4'-piperidine]-4-one derivatives as potential inhibitors of fatty acid synthesis in pathogens: Design, synthesis, and biological evaluation. Eur J Med Chem. 2023 Mar 15;250:115215. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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