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Cat. No.: HY-178672

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ARCA

Name: ARCA
Brand: MedChemExpress
SKU: HY-178672
Availability: PreOrder

(Synonyms: Anti-Reverse cap analog; m2 7,3′O GpppG)

ARCA (Anti-Reverse cap analog; m₂^7,3'OGpppG) is a 5′-cap analog. ARCA carries a methyl group at the 3'-OH position of m7G, which ensures that the cap is ligated to the 5' end of mRNA in the correct orientation during in vitro transcription and prevents reverse ligation. ARCA enhances the translation efficiency and stability of mRNA. In human immature dendritic cells, both the translation efficiency and total protein expression of ARCA-capped mRNA are higher than those of conventional m7GpppG-capped mRNA. ARCA can be used in research related to cancer, infectious diseases and mRNA vaccines.

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CAS No.: 400806-46-4
Formule: C₂₂H₃₁N₁₀O₁₈P₃
Masse moléculaire:816.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

ARCA Chemical Structure

CAS No.: 400806-46-4

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

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In Vitro

ARCA-capped mRNA serves as the reference for translational efficiency and total protein expression in human immature dendritic cells, with a total protein expression of 1.00 and translational efficiency of 1.00^[1].
ARCA enables proper cotranscriptional capping of in vitro transcribed mRNA by preventing reverse cap orientation, thereby supporting mRNA translation efficiency and stability^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 400806-46-4
Masse moléculaire 816.46
Formule C₂₂H₃₁N₁₀O₁₈P₃
SMILES

O=C1C([N+](C)=CN2[C@H]3[C@H](O)[C@H](OC)[C@@H](COP(OP(OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4O)(O)=O)(O)=O)([O-])=O)O3)=C2N=C(N)N1
Synonyms

Anti-Reverse cap analog; m2 7,3′O GpppG
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kowalska J, et al. Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes. Nucleic acids research. 2014;42(16):10245-64. [Content Brief]

[2]. Bednarczyk M, et al. Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9. ACS chemical biology. 2022 Jun 17;17(6):1460-1471.

[3]. Litvinova V R, et al. mRNA vaccine platform: mRNA production and delivery[J]. Russian Journal of Bioorganic Chemistry, 2023, 49(2): 220-235.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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- In Vitro
Chemical Information
Pureté et documentation
Références

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ARCA

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis