country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-128616

Copy Link Print Information

BNBC

BNBC is a human STING-specific agonist. BNBC activates STING-IRF3 signaling, induces the expression of inflammatory cytokines such as type I/III interferons, and promotes dendritic cell maturation and the establishment of an antiviral state. BNBC can be used for research on STING-mediated innate immunity, dendritic cell function, and viral infection.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 55171-63-6
Formule: C₁₈H₁₂BrNO₃
Masse moléculaire:370.20

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BNBC Chemical Structure

CAS No.: 55171-63-6

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

Innate ImmunityCytokines & ChemokinesViral InfectionAdaptive ImmunityCytokines and Chemokines

Innate Immunity

Cytokines & Chemokines

BNBC (up to 200 µM; 4 h) concentration-dependently activates ISG54 promoter-driven luciferase expression in HepAD38/cGAS-STING/ISG54Luc and HepG2/STING/ISG54Luc cells, but not in STINGΔC cells; BNBC shows no obvious cytotoxicity up to 200 μM, suggesting that it activates the cGAS-STING pathway, with the site of action possibly downstream of cGAS, at STING, or upstream^[1].
BNBC (6 h) induces IFN-β, IL-29, and TNF-α mRNA expression in a concentration-dependent manner in HepG2/STING cells, but has no effect on parental HepG2, HepG2/STINGΔC, or HepG2/mSTING cells^[1].
BNBC (6-18 h) induces IFN-β, IL-28A, and IL-6 mRNA expression and IFN-β secretion in THF cells; STING knockout completely blocks BNBC-induced IFN-β mRNA expression, whereas TRIF or IPS-1/MAVS knockout does not^[1].

Innate Immunity

NBC (100 μM; 2 h) induces human STING nuclear translocation, IRF3 phosphorylation, and IRF3 nuclear translocation; its STING translocation is independent of the CTD, but IRF3 activation depends on the STING CTD^[1].
BNBC (50 μM; 4-8 h) induces an innate proinflammatory cytokine gene expression profile consistent with STING activation in THF cells and upregulates components related to PRR and interferon signaling^[1].
BNBC (6 h) induces type I/III IFN expression and, to a lesser extent, TNF-α expression in human PBMCs^[1].

Viral Infection

BNBC (pretreatment for 8 h) reduces DENV, YFV, and ZIKV RNA levels in THF cells in a concentration-dependent manner, with maximum reductions of approximately 90-, 150-, and 800-fold, respectively^[1].

Innate Immunity

Adaptive Immunity

Cytokines and Chemokines

BNBC (100 μM; 6 h) induces IFN-β, IL-29, TNF-α, and IL-6 mRNA expression in human PBMC-derived dendritic cells; BNBC (50 μM; 48 h) induces CD80 expression, suggesting that it promotes
dendritic cell maturation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 55171-63-6
Masse moléculaire 370.20
Formule C₁₈H₁₂BrNO₃
SMILES

O=C(NC1=CC=CC=2C=CC=CC21)C=3C=C4OCOC4=CC3Br
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Zhang X, et al. Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist. ACS Infect Dis. 2019 Jul 12;5(7):1139-1149.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

BNBC

Activité biologique

Description

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

BNBC Related Classifications

HY-128616 Related Classifications

Bioz

Keywords

Your Recently Viewed Products