Ceronapril
Ceronapril (SQ 29852) is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with an IC50 of 36 nM.
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- CAS No.: 111223-26-8
- Formule: C21H33N2O6P
- Masse moléculaire:440.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 36 nM (ACE)[1]
Ceronapril (100 mg/kg; p.o.; single dose or twice daily for 3 days) blocks ACE in peripheral sites in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[2]
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Dosage:100 mg/kg
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Administration:PO, twice daily for 3 days or single daily dose
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Result:Showed clear inhibition of ACE in the 2 circumventricular organs-the subfornical organ and the lamina terminals-but no change in other regions of the brain after chronic treatment. Inhibited ACE in plasma, kidney and lung rapidly (3 hr) after a single administration. Did not inhibit ACE in structures of the brain within the blood-brain barrier, such as the caudate-putamen, choroid plexus, globus pallidus, supraoptic nucleus and paraventricular nucleus of the hypothalamus.
Chemical Information
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CAS No. 111223-26-8
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Masse moléculaire 440.47
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Formule C21H33N2O6P
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SMILES
O=P(CCCCC1=CC=CC=C1)(O)O[C@@H](CCCCN)C(N2[C@@H](CCC2)C(O)=O)=O
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Synonyms
Ceranapril; SQ 29852
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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