CLEC5A-IN-1
CLEC5A-IN-1 is an inhibitor that binds to CLEC5A, with a Kd value of 277 nM. CLEC5A-IN-1 inhibits HBV replication. CLEC5A-IN-1 induces the production of IFNα and IFNβ. CLEC5A-IN-1 reduces serum HBsAg and HBV DNA levels, as well as hepatic HBcAg levels, in HBV-infected animals. CLEC5A-IN-1 increases the positive rate and levels of serum HBsAb in HBV-infected animals. CLEC5A-IN-1 can be used for the research of hepatitis B.
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- CAS No.: 321941-76-8
- Formule: C21H27N3O9S2
- Masse moléculaire:529.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
CLEC5A-IN-1 (C4) (0.125-4 μM, 0-100 s) binds directly to purified CLEC5A protein, with a Kd of 277 nM[1].
CLEC5A-IN-1 (0.01-1000 μM; 72 h) exhibits low cytotoxicity against PMA (HY-18739)-induced THP-1 macrophages, with a CC50 of 770 μM[1].
CLEC5A-IN-1 (0.01-100 μM; 12 h pre-incubation with macrophage cells, 48 h co-culture with HepG2.2.15 cells) inhibits HBV replication in HepG2.2.15 cells co-cultured with PMA-induced THP-1 macrophages, with an IC50 of 20 μM[1].
CLEC5A-IN-1 (incubated with cells for 3 h, followed by incubation with Streptavidin Magnetic Beads (HY-K0208) at 4℃ for 2 h) directly binds to endogenous human CLEC5A in PMA-induced THP-1 macrophages, as well as mouse CLEC5A in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PMA-induced THP-1 macrophage cells
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Concentration:0, 0.01, 0.1, 1, 10, 20, 100, 1000 μM
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Incubation Time:72 h
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Result:Showed low cytotoxicity, with a CC50 (concentration causing 50% cell death) of 770 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (18-20g; HBV infection via hydrodynamic injection of 10 μg pAAV/HBV1.2, serum HBV DNA ≥5×106 copies/mL)[1]
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Dosage:400 μg/只
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Administration:i.p.; weekly; 20 weeks
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Result:Sustained reduced serum HBsAg, serum HBV DNA, and intrahepatic HBcAg levels.
Increased serum HBsAb positive rate, serum HBsAb levels, serum IFNα levels, and serum IFNβ levels.
Chemical Information
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CAS No. 321941-76-8
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Masse moléculaire 529.58
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Formule C21H27N3O9S2
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SMILES
O=S(=O)(C1=CC=C2C=3C=CC(=CC3C(=NO)C2=C1)S(=O)(=O)N(CCO)CCO)N(CCO)CCO
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CLEC5A-IN-1 Related Classifications
HY-184358 Related Classifications
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