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Cat. No.: HY-P11752

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Cyclo(KLARLLT)

Cyclo (KLARLLT) is an EGFR ligand with a K_d value of 1.16 μM. Cyclo (KLARLLT) binds to domain I of EGFR and interacts with both the open and closed conformations of EGFR. Cyclo (KLARLLT) is a modified variant of LARLLT (HY-P11078). Cyclo (KLARLLT) can be used in the research of colorectal cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₃₇H₆₉N₁₁O₈
Masse moléculaire:796.01

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Please store the product under the recommended conditions in the Certificate of Analysis.

Synthèse personnalisée de peptides

Cyclo(KLARLLT) Chemical Structure

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- In Vitro
Chemical Information
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform EGFR :

In Vitro

Cyclo (KLARLLT) (0-200 μM) binds to the purified extracellular domain of EGFR, with a K_D value of 1.16 μM^[1].
Cyclo (KLARLLT) binds to domain I of EGFR (including both open and closed conformations), and its low-energy structure is stabilized by hydrogen bonds and hydrophobic interactions^[1].
Cyclo (KLARLLT) (2 mg/mL; 0-48 h at 37°C) exhibits significantly improved stability in human serum compared with its linear analog KLARLLT; nearly 60% of the peptide remains intact after incubation at 37°C for 48 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 796.01
Formule C₃₇H₆₉N₁₁O₈
Sequence

Cyclo(Lys-Leu-Ala-Arg-Leu-Leu-Thr)
Sequence Shortening

Cyclo(KLARLLT)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Williams TM, et al. Peptide ligands for targeting the extracellular domain of EGFR: Comparison between linear and cyclic peptides. Chem Biol Drug Des. 2018;91(2):605-619. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
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Cyclo(KLARLLT)

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Cyclo(KLARLLT) Related Classifications

HY-P11752 Related Classifications