CyPep-1
CyPep-1 is a novel cationic lytic peptide with antitumor activity. CyPep-1 is highly cytotoxic by interacting with the negatively charged cell membrane of cancer cells. CyPep-1 has strong cytolytic activity on cancer cells both in vivo and in vitro, and can be used in the study of solid tumors.
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- CAS No.: 1319804-91-5
- Formule: C152H265N57O35
- Masse moléculaire:3451.09
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
CyPep-1 (0-40 μg/mL; 15-360 min) produces toxicity to tumor cell lines in a dose- and time-dependent manner, with little effect on normal cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4T1 murine metastatic breast cancer cells treated female BALB/c mice (average age 12625 days; average weight 23.8g)[1]
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Dosage:1200 µg
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Administration:Intratumoural injection; single dose
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Result:Did not cause any signs of discomfort, pain or toxicity.
Significantly reduced tumour growth and caused massive necrosis of the tumours.
Prolonged the median survival time of mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1319804-91-5
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Masse moléculaire 3451.09
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Formule C152H265N57O35
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Sequence
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Lys-Thr-Leu-Arg-Val-Ala-Lys-Ala-Ile-Tyr-Lys-Arg-Tyr-Ile-Glu
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Sequence Shortening
YGRKKRRQRRRGKTLRVAKAIYKRYIE
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CyPep-1 Related Classifications
HY-P10841 Related Classifications
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