Dideoxycytidinene
Based on 1 Customer Validation
Dideoxycytidinene (2′,3′-Didehydro-2′,3′-dideoxycytidine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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- Pureté: 98.36%
- CAS No.: 7481-88-1
- Formule: C9H11N3O3
- Masse moléculaire:209.20
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| ATH-8 cell line | ED50 |
0.3 μM
Compound: 2b
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Protection of ATH8 cells against the cytopathic effect of HIV.
Protection of ATH8 cells against the cytopathic effect of HIV.
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[PMID: 3497272] |
| CCRF-CEM | ED50 |
>20 μM
Compound: 1
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In vitro concentration required to decrease 50% of mitochondrial DNA content in CEM cells
In vitro concentration required to decrease 50% of mitochondrial DNA content in CEM cells
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[PMID: 8627596] |
| CCRF-CEM | ED50 |
20 μM
Compound: 1
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In vitro concentration required to inhibit 50% of CEM cell growth
In vitro concentration required to inhibit 50% of CEM cell growth
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[PMID: 8627596] |
| HepG2 | ED50 |
10 nM
Compound: 1
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Concentration required to inhibit 50% of extracellular circular replication of HBV DNA using 2215 cell line
Concentration required to inhibit 50% of extracellular circular replication of HBV DNA using 2215 cell line
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[PMID: 8627596] |
| HepG2 | ED50 |
8 nM
Compound: 1
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Concentration required to inhibit 50% of intracellular circular replication of HBV DNA using 2215 cell line
Concentration required to inhibit 50% of intracellular circular replication of HBV DNA using 2215 cell line
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[PMID: 8627596] |
| MT2 | ED50 |
1 μM
Compound: 1
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Concentration required to inhibit 50% of HIV activity in MT-2 cells
Concentration required to inhibit 50% of HIV activity in MT-2 cells
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[PMID: 8627596] |
| MT4 | ED50 |
0.13 μM
Compound: d4Cyd
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Effective dose achieving 50% protection of MT-4 cells against the cytopathic effect of HIV
Effective dose achieving 50% protection of MT-4 cells against the cytopathic effect of HIV
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[PMID: 2342078] |
Chemical Information
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CAS No. 7481-88-1
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Appearance Solid
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Masse moléculaire 209.20
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Formule C9H11N3O3
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Color White to light yellow
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SMILES
OC[C@@H]1C=C[C@H](N2C(N=C(N)C=C2)=O)O1
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Synonyms
2′,3′-Didehydro-2′,3′-dideoxycytidine
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dideoxycytidinene Related Classifications
HY-145791 Related Classifications
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