DOPE-PEG10000-NHS
DOPE-PEG1000-NHS is a conjugate composed of DOPE, PEG chains, and terminal active ester (NHS). The NHS ester in DOPE-PEG1000-NHS can rapidly covalently react with molecules containing primary amines (such as proteins, peptide chains, and small molecules modified with amino groups) to form stable amide bonds, suitable for the construction of carriers requiring membrane fusion properties or pH-sensitive release (such as gene delivery systems).
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- Masse moléculaire:10000 (Average)
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
The structure of DOPE-PEG-NHS comprises three key components that work synergistically:
DOPE: Containing two oleoyl groups (C18:1), it imparts excellent membrane fluidity and promotes membrane fusion under acidic conditions (such as endosome escape).
PEG chain: Acts as a hydrophilic spacer arm, forming a hydration layer on the particle surface, reducing non-specific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo.
NHS: Acts as a reaction interface, reacting efficiently with molecules containing primary amino groups (such as antibodies and peptides) under mild conditions to form stable covalent bonds.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 10000 (Average)
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SMILES
CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCCNC(COCCOCC(ON(C(CC1)=O)C1=O)=O)=O)(O)=O)=O.[n]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DOPE-PEG10000-NHS Related Classifications
HY-203300D Related Classifications
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