FGI-106
Based on 1 publication(s) in Google Scholar
FGI-106 is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively.
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- CAS No.: 501081-38-5
- Formule: C28H38N6
- Masse moléculaire:458.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) FGI-106
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Activité biologique
Description
IC50 & Target
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HIV-1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
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Antiviral activity against Dengue virus 1 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 1 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
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[PMID: 26771861] |
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
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Antiviral activity against Dengue virus 2 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 2 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
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[PMID: 26771861] |
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
|
Antiviral activity against Dengue virus 3 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 3 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
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[PMID: 26771861] |
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
|
Antiviral activity against Dengue virus 4 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 4 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
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[PMID: 26771861] |
In Vitro
Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM[1].
In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male or female C57BL/6 or BALB/c mice (6-10 weeks of age) injected with EBOV (Ebola virus)[1]
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Dosage:0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg
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Administration:Intraperitoneal injection; treatments on days 2 and 5
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Result:Decreased mortality from Zaire EBOV in a dose-dependent manner.
Chemical Information
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CAS No. 501081-38-5
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Masse moléculaire 458.64
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Formule C28H38N6
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SMILES
CC1=CC(NCCCN(C)C)=C2C=CC3=C4N=C(C)C=C(NCCCN(C)C)C4=CC=C3C2=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Bioorg Chem
Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]2024 Jun:147:107412. PMID: 38696845
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FGI-106 Related Classifications
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