Ddx3x - DEAD box helicase 3, X-linked Gene

Also Known as Ddx3; Fin14; D1Pas1-rs2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13205

Summary

Enables primary miRNA binding activity. Involved in positive regulation of NLRP3 inflammasome complex assembly and stress granule assembly. Acts upstream of or within with a negative effect on primary miRNA processing. Located in cytoplasmic stress granule. Part of NLRP3 inflammasome complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Ddx3x Products (1)

mRNA Protein Name
NM_010028.3 NP_034158.1 ATP-dependent RNA helicase DDX3X

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables primary miRNA binding IDA
IDA: Inferred from direct assay
28819115 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18583960 MGI
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
31511697 MGI
acts upstream of or within negative effect primary miRNA processing IDA
IDA: Inferred from direct assay
28819115 MGI
acts upstream of or within negative effect primary miRNA processing IMP
IMP: Inferred from mutant phenotype
28819115 MGI
involved in stress granule assembly IMP
IMP: Inferred from mutant phenotype
31511697 MGI
Cellular Component GO Annotation Evidence Références Source
part of NLRP3 inflammasome complex IDA
IDA: Inferred from direct assay
31511697 MGI
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
31511697 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DDX3X

  • D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3

  • D1Pas1-related sequence 2

  • DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3

  • DEAD box RNA helicase DEAD3

  • DEAD box protein 3, X-chromosomal

  • DEAD-box protein 3 (DEAD-box RNA

Ddx3x Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Ddx3x Q62167 TBK1 Homo sapiens Q9UHD2
Peptide Array
18583960
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS03646 DDX3X Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17503 Ddx3x Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23960 Ddx3x Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddx3x NCBI NCBI:1654