PROM2 - prominin 2 Gene

Also Known as PROML2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 150696

About PROM2

Cytogenetic location: 2q11.1 Genomic coordinates (GRCh38): 2:95,274,449-95,291,302 (from NCBI)

This gene has 11 transcripts (splice variants), 191 orthologues and 1 paralogue. Biased expression in skin (RPKM 29.4), esophagus (RPKM 22.9) and 11 other tissues.

Summary

This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

PROM2 Products (4)

mRNA Protein Name
NM_001165977.3 NP_001159449.1 prominin-2 isoform 1 precursor
NM_001165978.3 NP_001159450.1 prominin-2 isoform 1 precursor
NM_001321070.2 NP_001307999.1 prominin-2 isoform 2
NM_144707.4 NP_653308.2 prominin-2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of caveolin-mediated endocytosis IDA
IDA: Inferred from direct assay
23583380 GOA
involved in negative regulation of pinocytosis IDA
IDA: Inferred from direct assay
23583380 GOA
involved in positive regulation of cell projection organization IDA
IDA: Inferred from direct assay
23583380 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
23583380 GOA
involved in regulation of GTPase activity IDA
IDA: Inferred from direct assay
23583380 GOA
NOT involved in regulation of clathrin-dependent endocytosis IDA
IDA: Inferred from direct assay
23583380 GOA
Cellular Component GO Annotation Evidence Références Source
located in cell projection IDA
IDA: Inferred from direct assay
23583380 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROM2 Protein Structure

Prominin

Prominin: Prominin (19 - 816)

  • 0
  • 200
  • 400
  • 600
  • 834 a.a.
Protein Preferred Names Protein Names

prominin-2

  • prominin-like protein 2

PROM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
PROM2 Q8N271 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
PROM2 Q8N271 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
PROM2 Q8N271 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
PROM2 Q8N271 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
PROM2 Q8N271 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Maxillary Cancer

  • Maxillary Neoplasm

  • Maxillary Neoplasms

  • Upper Jaw Bone Cancer
Jaw Cancer

  • Jaw Neoplasms

  • Jaw Neoplasm

  • Neoplasm Of Jaw

  • Cancer Of Jaw
Retinal Degeneration

  • Degeneration Of Retina
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11199 PROM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PROM2 MGD MGI:2138997
Macaca mulatta PROM2 VGNC VGNC:106200
Canis familiaris PROM2 VGNC VGNC:45013
Bos taurus PROM2 VGNC VGNC:33365
Felis catus PROM2 VGNC VGNC:64367
Rattus norvegicus PROM2 RGD RGD:621435
Others PROM2 NCBI