GRK3 - G protein-coupled receptor kinase 3 Gene

Also Known as BARK2; ADRBK2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 157

About GRK3

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:25,564,675-25,729,294 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 7 paralogues. Broad expression in fat (RPKM 17.4), spleen (RPKM 8.7) and 22 other tissues.

Summary

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta Adrenergic Receptor kinase 2 has 85% amino acid similarity with beta Adrenergic Receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

GRK3 Products (2)

mRNA Protein Name
NM_001362778.2 NP_001349707.1 beta-adrenergic receptor kinase 2 isoform 2
NM_005160.4 NP_005151.2 beta-adrenergic receptor kinase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
23455922 GOA
Biological Process GO Annotation Evidence Références Source
involved in receptor internalization IDA
IDA: Inferred from direct assay
20074556 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRK3 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (55 - 174)

Pkinase

Pkinase: Protein kinase domain (192 - 453)

PH

PH: PH domain (559 - 651)

  • 0
  • 200
  • 400
  • 600
  • 688 a.a.
Protein Preferred Names Protein Names

beta-adrenergic receptor kinase 2

  • adrenergic, beta, receptor kinase 2

Related Diseases

Diseases Alias
Whim Syndrome 1

  • Whim Syndrome

  • Whims

  • Warts, Hypogammaglobulinemia, Infections, And Myelokathexis

  • WHIMS1

  • Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome

  • Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1

  • Myelokathexis, Isolated

  • Wilm

  • Warts-Infections-Leukopenia-Myelokatexis Syndrome

  • Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-103045A CMPD101 hydrochloride Inhibitor / Unkown
HY-RS05814 GRK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20749 Grk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27261 Grk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GRK3 VGNC VGNC:62719
Bos taurus GRK3 VGNC VGNC:53904
Mus musculus GRK3 MGD MGI:87941
Rattus norvegicus GRK3 RGD RGD:2063
Macaca mulatta GRK3 VGNC VGNC:73255
Canis familiaris GRK3 VGNC VGNC:41503
Others GRK3 NCBI