SEC31A - SEC31 homolog A, COPII coat complex component Gene

Also Known as HPBKS; ABP125; ABP130; HSPC275; HSPC334; NEDSOSB; SEC31L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22872

About SEC31A

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:82,818,509-82,900,569 (from NCBI)

This gene has 41 transcripts (splice variants), 208 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 48.8), thyroid (RPKM 42.6) and 25 other tissues.

Summary

The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

SEC31A Products (57)

mRNA Protein Name
NM_001077206.4 NP_001070674.1 protein transport protein Sec31A isoform 4
NM_001077207.4 NP_001070675.1 protein transport protein Sec31A isoform 1
NM_001077208.4 NP_001070676.1 protein transport protein Sec31A isoform 3
NM_001191049.2 NP_001177978.1 protein transport protein Sec31A isoform 5
NM_001300744.3 NP_001287673.1 protein transport protein Sec31A isoform 6
NM_001300745.3 NP_001287674.1 protein transport protein Sec31A isoform 7
NM_001318119.2 NP_001305048.1 protein transport protein Sec31A isoform 3
NM_001318120.2 NP_001305049.1 protein transport protein Sec31A isoform 1
NM_001400154.1 NP_001387083.1 protein transport protein Sec31A isoform 8
NM_001400155.1 NP_001387084.1 protein transport protein Sec31A isoform 8
NM_001400156.1 NP_001387085.1 protein transport protein Sec31A isoform 9
NM_001400157.1 NP_001387086.1 protein transport protein Sec31A isoform 10
NM_001400158.1 NP_001387087.1 protein transport protein Sec31A isoform 10
NM_001400159.1 NP_001387088.1 protein transport protein Sec31A isoform 10
NM_001400160.1 NP_001387089.1 protein transport protein Sec31A isoform 11
NM_001400161.1 NP_001387090.1 protein transport protein Sec31A isoform 32
NM_001400162.1 NP_001387091.1 protein transport protein Sec31A isoform 12
NM_001400164.1 NP_001387093.1 protein transport protein Sec31A isoform 1
NM_001400165.1 NP_001387094.1 protein transport protein Sec31A isoform 14
NM_001400166.1 NP_001387095.1 protein transport protein Sec31A isoform 1
NM_001400167.1 NP_001387096.1 protein transport protein Sec31A isoform 15
NM_001400168.1 NP_001387097.1 protein transport protein Sec31A isoform 15
NM_001400180.1 NP_001387109.1 protein transport protein Sec31A isoform 16
NM_001400184.1 NP_001387113.1 protein transport protein Sec31A isoform 17
NM_001400186.1 NP_001387115.1 protein transport protein Sec31A isoform 17
NM_001400188.1 NP_001387117.1 protein transport protein Sec31A isoform 16
NM_001400190.1 NP_001387119.1 protein transport protein Sec31A isoform 3
NM_001400191.1 NP_001387120.1 protein transport protein Sec31A isoform 3
NM_001400193.1 NP_001387122.1 protein transport protein Sec31A isoform 3
NM_001400194.1 NP_001387123.1 protein transport protein Sec31A isoform 18
NM_001400197.1 NP_001387126.1 protein transport protein Sec31A isoform 19
NM_001400198.1 NP_001387127.1 protein transport protein Sec31A isoform 20
NM_001400200.1 NP_001387129.1 protein transport protein Sec31A isoform 19
NM_001400202.1 NP_001387131.1 protein transport protein Sec31A isoform 20
NM_001400203.1 NP_001387132.1 protein transport protein Sec31A isoform 19
NM_001400204.1 NP_001387133.1 protein transport protein Sec31A isoform 21
NM_001400205.1 NP_001387134.1 protein transport protein Sec31A isoform 21
NM_001400206.1 NP_001387135.1 protein transport protein Sec31A isoform 21
NM_001400207.1 NP_001387136.1 protein transport protein Sec31A isoform 2
NM_001400208.1 NP_001387137.1 protein transport protein Sec31A isoform 22
NM_001400209.1 NP_001387138.1 protein transport protein Sec31A isoform 2
NM_001400210.1 NP_001387139.1 protein transport protein Sec31A isoform 23
NM_001400211.1 NP_001387140.1 protein transport protein Sec31A isoform 23
NM_001400212.1 NP_001387141.1 protein transport protein Sec31A isoform 24
NM_001400213.1 NP_001387142.1 protein transport protein Sec31A isoform 7
NM_001400214.1 NP_001387143.1 protein transport protein Sec31A isoform 25
NM_001400215.1 NP_001387144.1 protein transport protein Sec31A isoform 26
NM_001400216.1 NP_001387145.1 protein transport protein Sec31A isoform 27
NM_001400217.1 NP_001387146.1 protein transport protein Sec31A isoform 4
NM_001400218.1 NP_001387147.1 protein transport protein Sec31A isoform 28
NM_001400219.1 NP_001387148.1 protein transport protein Sec31A isoform 29
NM_001400220.1 NP_001387149.1 protein transport protein Sec31A isoform 29
NM_001400221.1 NP_001387150.1 protein transport protein Sec31A isoform 30
NM_001400222.1 NP_001387151.1 protein transport protein Sec31A isoform 30
NM_001400223.1 NP_001387152.1 protein transport protein Sec31A isoform 6
NM_001400224.1 NP_001387153.1 protein transport protein Sec31A isoform 31
NM_016211.5 NP_057295.2 protein transport protein Sec31A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
16957052 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16407955 GOA
Biological Process GO Annotation Evidence Références Source
involved in COPII-coated vesicle cargo loading IDA
IDA: Inferred from direct assay
17499046 GOA
involved in response to calcium ion IDA
IDA: Inferred from direct assay
17196169 GOA
Cellular Component GO Annotation Evidence Références Source
part of COPII vesicle coat IDA
IDA: Inferred from direct assay
17499046 GOA
located in COPII-coated ER to Golgi transport vesicle IDA
IDA: Inferred from direct assay
22358839 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17196169 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
17196169 GOA
located in endoplasmic reticulum exit site IDA
IDA: Inferred from direct assay
25201882 GOA
located in endoplasmic reticulum exit site IMP
IMP: Inferred from mutant phenotype
16957052 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17196169 GOA
part of vesicle coat IDA
IDA: Inferred from direct assay
22792322 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC31A Protein Structure

WD40

WD40: WD domain, G-beta repeat (251 - 285)

Sec16_C

Sec16_C: Sec23-binding domain of Sec16 (573 - 766)

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  • 1220 a.a.
Protein Preferred Names Protein Names

protein transport protein Sec31A

  • SEC31 homolog A, COPII coating complex component

SEC31A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SEC31A O94979 SEC13 Homo sapiens P55735
Anti Tag CoIP
35271311
Intra
SEC31A O94979 SEC13 Homo sapiens P55735
Cosedimentation
18692470
Intra
SEC31A O94979 SEC13 Homo sapiens P55735
Anti Tag CoIP
33961781
Intra
SEC31A O94979 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
SEC31A O94979 PDCD6 Homo sapiens O75340
Far-WB
17196169
Intra
SEC31A O94979 PDCD6 Homo sapiens O75340
Confocal
17196169
Intra
SEC31A O94979 SCYL1 Homo sapiens Q96KG9
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

SEC31A Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P89815 Sec31A Antibody (YA9159) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Halperin-Birk Syndrome

  • Neurodevelopmental Disorder With Spastic Quadriplegia, Optic Atrophy, Seizures, And Structural Brain Anomalies

  • NEDSOSB

  • HLBKS
Pseudobulbar Palsy

  • Pseudobulbar Paralysis
Spastic Quadriplegia

  • Spastic Quadriplegic Cerebral Palsy

  • Quadriplegic Infantile Cerebral Palsy

  • Tetraplegic Infantile Cerebral Palsy

  • Cerebral Palsy Spastic Quadriplegic

  • Quadriplegic Cerebral Palsy

  • Spastic Quadriplegia Cerebral Palsy

  • Spastic Tetraplegia Cerebral Palsy

  • Cerebral Palsy, Quadriplegic, Infantile

  • Cerebral Palsy With Spastic Tetraplegia

  • Congenital Spastic Quadriplegia

  • Spastic Tetraplegic Cerebral Palsy

  • Congenital Quadriplegia Nos

  • Tetraplegic Cerebral Palsy
Epithelioid Inflammatory Myofibroblastic Sarcoma
Quadriplegia

  • Tetraplegia

  • Tetraplegias
Semilobar Holoprosencephaly
Inflammatory Myofibroblastic Tumor

  • Inflammatory Fibrosarcoma
Craniolenticulosutural Dysplasia

  • Boyadjiev-Jabs Syndrome

  • CLSD

  • Cranio-Lenticulo-Sutural Dysplasia

  • Cranio-Lenticulo-Sutural Dysplasia, Clsd
Chylomicron Retention Disease

  • CMRD

  • Anderson Disease

  • Lipid Transport Defect Of Intestine

  • Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells

  • Andd

  • Anderson Syndrome

  • Crd

  • Andersons Disease

  • Malabsorption Syndrome
Holoprosencephaly

  • Holoprosencephaly Sequence

  • Hpe

  • Hpe - [Holoprosencephaly]
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS12619 SEC31A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SEC31A VGNC VGNC:77256
Bos taurus SEC31A VGNC VGNC:34417
Felis catus SEC31A VGNC VGNC:64971
Rattus norvegicus SEC31A RGD RGD:620233
Canis familiaris SEC31A VGNC VGNC:45976
Mus musculus SEC31A MGD MGI:1916412
Others SEC31A NCBI