ELP5 - elongator acetyltransferase complex subunit 5 Gene

Also Known as DERP6; MST071; HSPC002; MSTP071; C17orf81

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23587

About ELP5

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,251,724-7,259,940 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 177 orthologues. Broad expression in testis (RPKM 39.1), brain (RPKM 8.9) and 24 other tissues.

Summary

Predicted to contribute to tRNA binding activity. Predicted to be involved in positive regulation of cell migration and tRNA modification. Located in cytosol and nucleoplasm. Part of elongator holoenzyme complex. [provided by Alliance of Genome Resources, Apr 2022]

ELP5 Products (4)

mRNA Protein Name
NM_015362.5 NP_056177.4 elongator complex protein 5 isoform 1
NM_203413.3 NP_981958.2 elongator complex protein 5 isoform 2
NM_203414.3 NP_981959.2 elongator complex protein 5 isoform 1
NM_203415.4 NP_981960.2 elongator complex protein 5 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22854966 GOA
part of elongator holoenzyme complex IDA
IDA: Inferred from direct assay
22854966 GOA
part of elongator holoenzyme complex IPI
IPI: Inferred from physical interaction
22854966 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22854966 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELP5 Protein Structure

Elong_Iki1

Elong_Iki1: Elongator subunit Iki1 (17 - 298)

  • 0
  • 100
  • 200
  • 300
  • 316 a.a.
Protein Preferred Names Protein Names

elongator complex protein 5

  • S-phase 2 protein

ELP5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
ELP5 Q8TE02 ELP6 Homo sapiens Q0PNE2
Anti Tag CoIP
22854966
Intra
ELP5 Q8TE02 ELP4 Homo sapiens Q96EB1
Anti Tag CoIP
22854966
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tomato Allergy

  • Solanum Lycopersicum Fruit Allergy
Neuropathy, Hereditary Sensory And Autonomic, Type Iii

  • Familial Dysautonomia

  • Riley-Day Syndrome

  • Dysautonomia, Familial

  • HSAN3

  • Hsan Iii

  • Fd

  • Hereditary Sensory And Autonomic Neuropathy Type Iii

  • Dys

  • Hereditary Sensory And Autonomic Neuropathy 3

  • Riley Day Syndrome

  • Familial Autonomic Nervous Dysfunction

  • Hereditary Sensory Autonomic Neuropathy Type Iii

  • Hsan 3

  • Hsn 3

  • Hereditary Sensory Neuropathy Type 3

  • Hsan Type Iii

  • Hsn-Iii

  • Hereditary Sensory And Autonomic Neuropathy Type 3

  • Neuropathy, Hereditary Sensory And Autonomic, 3

  • Hsn Iii

  • Dysautonomia Familial

  • Neuropathy, Sensory And Autonomic, Hereditary, Type Iii

  • Hsan3 - [Hereditary Sensory And Autonomic Neuropathy Type 3]
Benign Epilepsy With Centrotemporal Spikes

  • Rolandic Epilepsy

  • Benign Rolandic Epilepsy

  • Epilepsy, Rolandic

  • Bcects

  • Benign Childhood Epilepsy With Centrotemporal Spike

  • Sylvan Seizures

  • Becrs

  • Bects

  • Bre

  • Benign Epilepsy Of Childhood With Centrotemporal Spikes

  • Benign Familial Epilepsy Of Childhood With Rolandic Spikes

  • Centrotemporal Epilepsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04332 ELP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ELP5 VGNC VGNC:72146
Bos taurus ELP5 VGNC VGNC:28458
Mus musculus ELP5 MGD MGI:1859017
Canis familiaris ELP5 VGNC VGNC:40329
Felis catus ELP5 VGNC VGNC:61829
Rattus norvegicus ELP5 RGD RGD:1303303
Others ELP5 NCBI