LY96 - lymphocyte antigen 96 Gene

Also Known as MD2; MD-2; ly-96; ESOP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23643

About LY96

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,991,392-74,099,857 (from NCBI)

This gene has 2 transcripts (splice variants) and 111 orthologues. Broad expression in spleen (RPKM 8.6), appendix (RPKM 8.4) and 22 other tissues.

Summary

This gene encodes a protein which associates with Toll-like Receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

LY96 Products (2)

mRNA	Protein	Name
NM_001195797.2	NP_001182726.1	lymphocyte antigen 96 isoform 2 precursor
NM_015364.5	NP_056179.4	lymphocyte antigen 96 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables lipopolysaccharide immune receptor activity	IDA IDA: Inferred from direct assay	19252480	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15728506	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in detection of lipopolysaccharide	IDA IDA: Inferred from direct assay	19252480	GOA
acts upstream of or within response to lipopolysaccharide	IDA IDA: Inferred from direct assay	12594207	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	14607928	GOA
involved in toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	14607928	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of lipopolysaccharide receptor complex	IDA IDA: Inferred from direct assay	11274165	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11274165	GOA
part of receptor complex	IPI IPI: Inferred from physical interaction	19252480	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LY96 Protein Structure

E1_DerP2_DerF2

0
100
160 a.a.

Protein Preferred Names	Protein Names
lymphocyte antigen 96	myeloid differentiation protein-2

LY96 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	LY96	Q9Y6Y9	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	LY96	Q9Y6Y9	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	LY96	Q9Y6Y9	TLR4	Homo sapiens	O00206-1	GMS	19252480
Intra	LY96	Q9Y6Y9	TLR4	Homo sapiens	O00206-1	Solid Phase Assay	22474354
Intra	LY96	Q9Y6Y9	TLR4	Homo sapiens	O00206-1	X-Ray Diffraction	19252480
Intra	LY96	Q9Y6Y9	TLR4	Homo sapiens	O00206	Anti Tag CoIP	15728506
Intra	LY96	Q9Y6Y9	TLR4	Homo sapiens	O00206	Crosslink	17803912
Intra	LY96	Q9Y6Y9	TLR4	Homo sapiens	O00206	GMS	17803912
Intra	LY96	Q9Y6Y9	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	LY96	Q9Y6Y9	MESD	Homo sapiens	Q14696	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LY96 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P79098	MD-2/LY96 Protein, Human (His)	Q9Y6Y9-1/BAA78717 (E17-N160)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P701067	MD-2/LY96 Protein, Human (142a.a, His)	Q9Y6Y9-1 (Q19-N160)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Melioidosis	Melioidosis, Susceptibility To Acute And Fulminating Melioidosis Nightcliff Gardener'S Disease Pseudoglanders Subacute And Chronic Melioidosis Burkholderia Pseudomallei Infection Whitmore Disease Whitmore'S Disease B Pseudomallei Infection Epizootic Lymphangitis Infection Due To Burkholderia Pseudomallei Infection Due To Burkholderia Pseudomallei Nos Infection Due To Malleomyces Pseudomallei Infection Due To Pseudomonas Pseudomallei Infection Due To Pseudomonas Pseudomallei Nos Infection Due To Whitmore Bacillus Stanton Disease
Toxic Shock Syndrome	Septic Shock Toxic Shock Tss Shock, Septic Staphylococcal Toxic Shock Syndrome Tss - [Toxic Shock Syndrome]
Thyrotoxic Exophthalmos
Endocrine Exophthalmos	Endocrine Exopthalmos Thyroid Associated Opthalmopathies
Inflammatory Bowel Disease 20	IBD20
Acute Gonococcal Cervicitis	Gonococcal Cervicitis Acute Gonorrhea Of Cervix
Bacterial Sepsis
Niemann-Pick Disease, Type C2	NPC2 Niemann-Pick Disease Type C2 Niemann-Pick C2 Disease Niemann-Pick Disease C2
Wheat Allergy	Wheat Allergic Reaction Wheat Hypersensitivity Allergy To Wheat Allergy Wheat
Acute Cervicitis
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Cataract 30	Cataract 30 Pulverulent Cataract Coppock-Like Ctrct30 Dusty Cataract Cataract, Type 30
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS07908	LY96 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19614	Ly96 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26109	Ly96 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LY96	MGD	MGI:1341909
Rattus norvegicus	LY96	RGD	RGD:1302993
Bos taurus	LY96	VGNC	VGNC:53867
Canis familiaris	LY96	VGNC	VGNC:42878
Felis catus	LY96	VGNC	VGNC:63335
Macaca mulatta	LY96	VGNC	VGNC:74303
Others	LY96	NCBI