GTF3C2 - general transcription factor IIIC subunit 2 Gene

Also Known as TF3C-beta; TFIIIC110; TFIIIC-BETA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2976

About GTF3C2

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,325,854-27,356,764 (from NCBI)

This gene has 13 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in thyroid (RPKM 13.6), skin (RPKM 10.5) and 25 other tissues.

Summary

Contributes to DNA binding activity. Involved in transcription by RNA polymerase III. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]

GTF3C2 Products (17)

mRNA Protein Name
NM_001035521.3 NP_001030598.1 general transcription factor 3C polypeptide 2 isoform b
NM_001318909.4 NP_001305838.2 general transcription factor 3C polypeptide 2 isoform b
NM_001388380.3 NP_001375309.2 general transcription factor 3C polypeptide 2 isoform b
NM_001394503.1 NP_001381432.1 general transcription factor 3C polypeptide 2 isoform b
NM_001394504.1 NP_001381433.1 general transcription factor 3C polypeptide 2 isoform b
NM_001394505.1 NP_001381434.1 general transcription factor 3C polypeptide 2 isoform b
NM_001394506.1 NP_001381435.1 general transcription factor 3C polypeptide 2 isoform b
NM_001394507.1 NP_001381436.1 general transcription factor 3C polypeptide 2 isoform b
NM_001394508.1 NP_001381437.1 general transcription factor 3C polypeptide 2 isoform b
NM_001394509.1 NP_001381438.1 general transcription factor 3C polypeptide 2 isoform b
NM_001394510.1 NP_001381439.1 general transcription factor 3C polypeptide 2 isoform b
NM_001394511.1 NP_001381440.1 general transcription factor 3C polypeptide 2 isoform b
NM_001394512.1 NP_001381441.1 general transcription factor 3C polypeptide 2 isoform d
NM_001394514.1 NP_001381443.1 general transcription factor 3C polypeptide 2 isoform e
NM_001394515.1 NP_001381444.1 general transcription factor 3C polypeptide 2 isoform f
NM_001394516.1 NP_001381445.1 general transcription factor 3C polypeptide 2 isoform g
NM_001521.4 NP_001512.1 general transcription factor 3C polypeptide 2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
contributes to DNA binding IDA
IDA: Inferred from direct assay
17409385 GOA
enables RNA polymerase III general transcription initiation factor activity IDA
IDA: Inferred from direct assay
17409385 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17409385 GOA
Biological Process GO Annotation Evidence Références Source
involved in transcription by RNA polymerase III IDA
IDA: Inferred from direct assay
17409385 GOA
Cellular Component GO Annotation Evidence Références Source
part of transcription factor TFIIIC complex IDA
IDA: Inferred from direct assay
17409385 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF3C2 Protein Structure

WD40

WD40: WD domain, G-beta repeat (607 - 642)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 911 a.a.
Protein Preferred Names Protein Names

general transcription factor 3C polypeptide 2

  • TFIIIC 110 kDa subunit

GTF3C2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
GTF3C2 Q8WUA4 RPTOR Homo sapiens Q8N122
Anti Bait CoIP
20543138
Intra
GTF3C2 Q8WUA4 GTF3C1 Homo sapiens Q12789
Anti Tag CoIP
33961781
Intra
GTF3C2 Q8WUA4 GTF3C1 Homo sapiens Q12789
Anti Bait CoIP
20543138
Intra
GTF3C2 Q8WUA4 MTOR Homo sapiens P42345
Anti Bait CoIP
20543138
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Paraphimosis
Proprotein Convertase 1/3 Deficiency

  • Obesity Due To Prohormone Convertase I Deficiency

  • Obesity With Impaired Prohormone Processing

  • Obesity And Endocrinopathy Due To Impaired Processing Of Prohormones

  • Pci Deficiency

  • Proprotein Convertase 1 3 Deficiency

  • Endocrinopathy Due To Proprotein Convertase 1/3 Deficiency

  • Proprotein Convertase 1 Deficiency

  • PC1 DEFICIENCY
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS05907 GTF3C2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GTF3C2 VGNC VGNC:41552
Mus musculus GTF3C2 MGD MGI:1919002
Felis catus GTF3C2 VGNC VGNC:67504
Macaca mulatta GTF3C2 VGNC VGNC:82153
Bos taurus GTF3C2 VGNC VGNC:29703
Rattus norvegicus GTF3C2 RGD RGD:1560392
Others GTF3C2 NCBI