DPP7 - dipeptidyl peptidase 7 Gene

Also Known as QPP; DPP2; DPPII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29952

About DPP7

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,110,546-137,118,306 (from NCBI)

This gene has 13 transcripts (splice variants), 191 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 29.2), testis (RPKM 27.1) and 25 other tissues.

Summary

The protein encoded by this gene is a post-proline cleaving Aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of Apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]

DPP7 Products (1)

mRNA Protein Name
NM_013379.3 NP_037511.2 dipeptidyl peptidase 2 preproprotein

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence Références Source
located in vesicle IDA
IDA: Inferred from direct assay
11067927 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPP7 Protein Structure

Peptidase_S28

Peptidase_S28: Serine carboxypeptidase S28 (38 - 464)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 492 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 2

  • DPP II

Recombinant DPP7 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P75280 DPP2 Protein, Human (HEK293, His) Q9UHL4 (G22-L492) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Periodontitis, Chronic

  • Chronic Periodontitis

  • Periodontitis, Adult
Complement Component 7 Deficiency

  • C7 Deficiency

  • C7D
Facial Hemiatrophy

  • Parry-Romberg Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS03967 DPP7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18350 Dpp7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24829 Dpp7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DPP7 VGNC VGNC:82328
Rattus norvegicus DPP7 RGD RGD:71073
Canis familiaris DPP7 VGNC VGNC:40076
Bos taurus DPP7 VGNC VGNC:28188
Mus musculus DPP7 MGD MGI:1933213
Macaca mulatta DPP7 VGNC VGNC:103257
Others DPP7 NCBI