EXOC2 - exocyst complex component 2 Gene

Also Known as SEC5; Sec5p; SEC5L1; NEDFACH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55770

About EXOC2

Cytogenetic location: 6p25.3 Genomic coordinates (GRCh38): 6:485,154-693,139 (from NCBI)

This gene has 3 transcripts (splice variants), 212 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 4.7), thyroid (RPKM 3.9) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

EXOC2 Products (1)

mRNA Protein Name
NM_018303.6 NP_060773.3 exocyst complex component 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
12459492 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
24056301 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
24056301 GOA
Biological Process GO Annotation Evidence Références Source
involved in Golgi to plasma membrane transport IMP
IMP: Inferred from mutant phenotype
32639540 GOA
involved in regulation of entry of bacterium into host cell IMP
IMP: Inferred from mutant phenotype
20579884 GOA
involved in vesicle docking involved in exocytosis IDA
IDA: Inferred from direct assay
12459492 GOA
Cellular Component GO Annotation Evidence Références Source
part of exocyst IDA
IDA: Inferred from direct assay
24056301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXOC2 Protein Structure

TIG

TIG: IPT/TIG domain (8 - 90)

Sec5

Sec5: Exocyst complex component Sec5 (200 - 377)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 924 a.a.
Protein Preferred Names Protein Names

exocyst complex component 2

  • SEC5-like 1

EXOC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
EXOC2 Q96KP1 EXOC1 Homo sapiens Q9NV70
TAP
27173435
Intra
EXOC2 Q96KP1 EXOC1 Homo sapiens Q9NV70
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

EXOC2 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P86868 EXOC2 Antibody (YA6561) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Dysmorphic Facies And Cerebellar Hypoplasia

  • NEDFACH
Ventricular Septal Defect

  • Ventricular Septal Defects

  • Interventricular Septal Defect

  • Heart Septal Defects, Ventricular

  • Ventricular Septal Abnormality

  • Interventricular Septum Defect

  • Ventricular Septum Defect

  • Vsd - [Ventricular Septum Defect]

  • Congenital Ventricular Septal Defect

  • Single Ventricular Septal Defect
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04588 EXOC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22497 Exoc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EXOC2 VGNC VGNC:28644
Mus musculus EXOC2 MGD MGI:1913732
Macaca mulatta EXOC2 VGNC VGNC:72338
Felis catus EXOC2 VGNC VGNC:61998
Rattus norvegicus EXOC2 RGD RGD:619961
Canis familiaris EXOC2 VGNC VGNC:40513
Others EXOC2 NCBI