TAGLN2 - transgelin 2 Gene

Also Known as HA1756

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8407

About TAGLN2

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,918,111-159,925,507 (from NCBI)

This gene has 5 transcripts (splice variants), 150 orthologues and 5 paralogues. Ubiquitous expression in lung (RPKM 268.8), stomach (RPKM 231.0) and 25 other tissues.

Summary

The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

TAGLN2 Products (3)

mRNA Protein Name
NM_001277223.2 NP_001264152.1 transgelin-2 isoform b
NM_001277224.2 NP_001264153.1 transgelin-2 isoform a
NM_003564.3 NP_003555.1 transgelin-2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
21577206 GOA
Biological Process GO Annotation Evidence Références Source
involved in epithelial cell differentiation IDA
IDA: Inferred from direct assay
21492153 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAGLN2 Protein Structure

CH

CH: Calponin homology (CH) domain (27 - 133)

Calponin

Calponin: Calponin family repeat (174 - 198)

  • 0
  • 100
  • 199 a.a.
Protein Preferred Names Protein Names

transgelin-2

  • SM22-alpha homolog

TAGLN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TAGLN2 P37802 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
TAGLN2 P37802 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
TAGLN2 P37802 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
TAGLN2 P37802 TAGLN3 Homo sapiens Q9UI15
Anti Tag CoIP
33961781
Intra
TAGLN2 P37802 TAGLN3 Homo sapiens Q9UI15
Anti Tag CoIP
28514442
Intra
TAGLN2 P37802 ACTB Homo sapiens P60709
Anti Tag CoIP
21577206
Intra
TAGLN2 P37802 SMN1 Homo sapiens Q16637
Validated Y2H
32814053
Intra
TAGLN2 P37802 SMN1 Homo sapiens Q16637
Y2H Array
32814053
Intra
TAGLN2 P37802 SMN1 Homo sapiens Q16637
Y2H Pooling
32814053
Intra
TAGLN2 P37802 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
TAGLN2 P37802 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
TAGLN2 P37802 HTT Homo sapiens P42858
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

TAGLN2 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P811236 Transgelin-2 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Barrett'S Adenocarcinoma

  • Barrett Adenocarcinoma

  • Adenocarcinoma Arising In Barrett'S Mucosa
Maxillary Sinus Cancer

  • Malignant Neoplasm Of Antrum

  • Malignant Tumor Of The Maxillary Sinus

  • Maxillary Sinus Carcinoma

  • Cancer Of Maxillary Sinus

  • Maxillary Sinus Neoplasms
Maxillary Sinus Squamous Cell Carcinoma

  • Epidermoid Carcinoma Of The Maxillofacial Sinus
Esophagus Adenocarcinoma

  • Esophageal Adenocarcinoma

  • Oesophageal Adenocarcinoma

  • Adenocarcinoma Of Esophagus

  • Adenocarcinoma Of The Esophagus
Neural Tube Defects

  • Spina Bifida

  • Neural Tube Defect

  • NTD

  • Neural Tube Defects, Susceptibility To

  • Spinal Dysraphism

  • Spina Bifida, Susceptibility To

  • Rachischisis

  • Cleft Spine

  • Open Spine

  • Hydrocele Spinalis

  • Neural Tube Defect Nos

  • Sb - [Spina Bifida]

  • Spinal Hernia Nos

  • Spinal Fissure Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14187 TAGLN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20602 Tagln2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27110 Tagln2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TAGLN2 VGNC VGNC:65944
Canis familiaris TAGLN2 VGNC VGNC:47094
Mus musculus TAGLN2 MGD MGI:1312985
Bos taurus TAGLN2 VGNC VGNC:35586
Rattus norvegicus TAGLN2 RGD RGD:1310840
Others TAGLN2 NCBI