SLC16A5 - solute carrier family 16 member 5 Gene

Also Known as MCT5; MCT6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9121

About SLC16A5

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,087,385-75,110,149 (from NCBI)

This gene has 10 transcripts (splice variants), 269 orthologues and 13 paralogues. Broad expression in lung (RPKM 9.8), duodenum (RPKM 9.3) and 21 other tissues.

Summary

This gene encodes a member of the Monocarboxylate Transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

SLC16A5 Products (3)

mRNA Protein Name
NM_001271765.2 NP_001258694.1 monocarboxylate transporter 6
NM_001369668.1 NP_001356597.1 monocarboxylate transporter 6
NM_004695.4 NP_004686.1 monocarboxylate transporter 6

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC16A5 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (32 - 297)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

monocarboxylate transporter 6

  • monocarboxylate transporter 5

SLC16A5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SLC16A5 O15375 HSPB8 Homo sapiens Q9UJY1
Y2H Prey Pooling
32296183
Intra
SLC16A5 O15375 HSPB8 Homo sapiens Q9UJY1
Validated Y2H
32296183
Intra
SLC16A5 O15375 HSPB8 Homo sapiens Q9UJY1
Y2H Array
32296183
Intra
SLC16A5 O15375 EFEMP2 Homo sapiens O95967
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Allan-Herndon-Dudley Syndrome

  • AHDS

  • Allan-Herndon Syndrome

  • Monocarboxylate Transporter 8 Deficiency

  • MCT8 DEFICIENCY

  • Mental Retardation, X-Linked, With Hypotonia

  • Triiodothyronine Resistance

  • T3 Resistance

  • Mental Retardation And Muscular Atrophy

  • Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency

  • Intellectual Disability And Muscular Atrophy

  • Monocarboxylate Transporter-8 Deficiency

  • T3 Resisitence

  • Triiodothyronine Resistence

  • X-Linked Intellectual Disability With Hypotonia

  • Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency

  • Monocarboxylate Transporter 8 Deficiency

  • X-Linked Intellectual Disability-Hypotonia Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13027 SLC16A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22031 Slc16a5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28549 Slc16a5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC16A5 MGD MGI:2443515
Macaca mulatta SLC16A5 VGNC VGNC:99257
Rattus norvegicus SLC16A5 RGD RGD:1582896
Bos taurus SLC16A5 VGNC VGNC:34691
Felis catus SLC16A5 VGNC VGNC:65212
Others SLC16A5 NCBI