NOLC1 - nucleolar and coiled-body phosphoprotein 1 Gene

Also Known as P130; Srp40; NOPP130; NOPP140; NS5ATP13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9221

About NOLC1

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,152,389-102,163,870 (from NCBI)

This gene has 9 transcripts (splice variants) and 171 orthologues. Ubiquitous expression in brain (RPKM 23.0), thyroid (RPKM 22.8) and 25 other tissues.

Summary

Enables protein heterodimerization activity and protein-macromolecule adaptor activity. Involved in neural crest cell development; neural crest formation; and regulation of translation. Located in fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]

NOLC1 Products (3)

mRNA Protein Name
NM_001284388.2 NP_001271317.1 nucleolar and coiled-body phosphoprotein 1 isoform 1
NM_001284389.2 NP_001271318.1 nucleolar and coiled-body phosphoprotein 1 isoform 3
NM_004741.5 NP_004732.2 nucleolar and coiled-body phosphoprotein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables molecular function inhibitor activity EXP
EXP: Inferred from Experiment
22906532 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17620599 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
26399832 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
26399832 GOA
Biological Process GO Annotation Evidence Références Source
involved in neural crest cell development IMP
IMP: Inferred from mutant phenotype
26399832 GOA
involved in neural crest formation IMP
IMP: Inferred from mutant phenotype
26399832 GOA
involved in regulation of translation IMP
IMP: Inferred from mutant phenotype
26399832 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOLC1 Protein Structure

SRP40_C

SRP40_C: SRP40, C-terminal domain (624 - 696)

  • 0
  • 200
  • 400
  • 600
  • 699 a.a.
Protein Preferred Names Protein Names

nucleolar and coiled-body phosphoprotein 1

  • 140 kDa nucleolar phosphoprotein

NOLC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
NOLC1 Q14978 ARRB2 Homo sapiens P32121
Anti Tag CoIP
17620599
Intra
NOLC1 Q14978 ARRB1 Homo sapiens P49407
Anti Tag CoIP
17620599
Cross: Cross-species interaction Intra: Intraspecies interaction

NOLC1 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P81671 NOLC1 Antibody (YA1416) WB, IHC-F, IHC-P, ICC/IF Human
HY-P81671A NOLC1 Antibody (YA1416)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Hepatitis C Virus

  • Hepatitis C Virus, Susceptibility To

  • Hepatitis C Virus Infection, Response To Therapy Of

  • Hcv

  • Hcv, Susceptibility To

  • Hepatitis C Virus, Resistance To

  • Hepatitis C Virus, Response To Therapy Of

  • Resistance To Hepatitis C Virus
Lissencephaly

  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria
Treacher Collins Syndrome 1

  • Treacher Collins Syndrome

  • Mandibulofacial Dysostosis

  • Treacher Collins-Franceschetti Syndrome

  • Tcof

  • Tcs

  • Mfd1

  • Franceschetti-Klein Syndrome

  • TCS1

  • Franceschetti Syndrome

  • Franceschetti-Zwahlen-Klein Syndrome

  • Zygoauromandibular Dysplasia

  • Treacher-Collins Syndrome

  • Mandibulofacial Dysostosis Without Limb Anomalies

  • Bilateral And Symmetric Oto-Mandibular Dysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09420 NOLC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NOLC1 VGNC VGNC:43885
Macaca mulatta NOLC1 VGNC VGNC:75178
Bos taurus NOLC1 VGNC VGNC:32161
Mus musculus NOLC1 MGD MGI:1918019
Rattus norvegicus NOLC1 RGD RGD:621578
Felis catus NOLC1 VGNC VGNC:63854
Others NOLC1 NCBI