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Cat. No.: HY-N5006

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Guanfu base G

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Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC₅₀ of 17.9 μM.

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Pureté: 99.91%
CAS No.: 78969-72-9
Formule: C₂₆H₃₃NO₇
Masse moléculaire:471.54

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Guanfu base G Chemical Structure

CAS No.: 78969-72-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC₅₀ of 17.9 μM^[1]^[2].

IC₅₀ & Target

IC50: 17.9 μM (HERG channel)^[2]

In Vitro

The effects of Guanfu base G is investigated in human embryonic kidney 293 (HEK293) cells transiently transfected with HERG complementary DNA using a whole-cell patch clamp technique. Guanfu base G inhibits HERG channel current in concentration-, voltage-, and time-dependent manners. Guanfu base G shifts the activation curve in a negative direction and accelerated channel inactivation but shows no effect on the inactivation curve. Moreover, Guanfu base G also accelerates channel recovery from inactivation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Guanfu base G (5 mg/kg; intravenous injection; for 5-1200 minutes; rats) treatment in rats after 15 min could be detected the presence of Guanfu base A, about 10% of Guanfu base G in vivo could metabolize to Guanfu base A, which may be related to the metabolic enzymes in the body and its nature-related compounds, however, the substance in the body to eliminate more quickly, could be detected only around 240 min. The pharmacokinetic behavior of Guanfu base G is better in rats, the T_1/2 is 4.16 hours. These results indicate that Guanfu base G has a relatively suitable elimination half-life^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats^[1]
Dosage:

5 mg/kg
Administration:

Intravenous injection; for 5, 15, 30, 45, 60, 120, 240, 360, 480, 600, 720, 960 and 1200 minutes (Pharmacokinetic study)
Result:

The pharmacokinetic behavior was better in rats, the T_1/2 was 4.16 hours.

Chemical Information

CAS No. 78969-72-9
Appearance Solid
Masse moléculaire 471.54
Formule C₂₆H₃₃NO₇
Color White to off-white
SMILES

CC(O[C@H]([C@]1([H])[C@H]2OC(C)=O)[C@@]3([H])[C@@]45C6[C@]2(O)C3(CC1=C)C[C@@]7([H])[C@]4([H])[C@@](C)(C[C@H](OC(C)=O)C5)C[N@]67)=O
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (281 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang L, et al. Simultaneous determination of Guanfu base G and its active metabolites by UPLC-MS/MS in rat plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:1-6. [Content Brief]

[2]. Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Guanfu base G

Membrane Transporter/Ion Channel Compound Library

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Anti-Cardiovascular Disease Compound Library

Anti-Alzheimer's Disease Compound Library

Alkaloids Library

Neurodegenerative Disease-related Compound Library

Plant-Sourced Natural Product Library

Potassium Channel Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Cardiotoxic Compound Library

Mass Spectrometry Natural Product Library

Activité biologique

Chemical Information

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Guanfu base G

Membrane Transporter/Ion Channel Compound Library

Natural Product Library

Anti-Cardiovascular Disease Compound Library

Anti-Alzheimer's Disease Compound Library

Alkaloids Library

Neurodegenerative Disease-related Compound Library

Plant-Sourced Natural Product Library

Potassium Channel Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Cardiotoxic Compound Library

Mass Spectrometry Natural Product Library

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Guanfu base G Related Classifications

HY-N5006 Related Classifications