Harzianoside A
Harzianoside A is a diterpene aminoglycoside compound discovered from Trichoderma sp. SCSIOW21. Harzianoside A has the activity of inhibiting the production of NO and can be used in the research of the anti-inflammatory field.
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- CAS No.: 3075431-09-0
- Formule: C28H43NO7
- Masse moléculaire:505.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
Chemical Information
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CAS No. 3075431-09-0
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Masse moléculaire 505.64
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Formule C28H43NO7
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SMILES
CC1([C@@]([C@@H](C2)C)(CCC(C)=C3C4=O)[C@](C[C@]1([H])[C@H]2O[C@@H](O[C@@H]5CO)[C@@H]([C@H]([C@@H]5O)O)NC(C)=O)([H])[C@@]3(C4)C)C
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Structure Classification
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Initial Source
Trichoderma sp.
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Harzianoside A Related Classifications
HY-N15507 Related Classifications
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