HS014
Based on 1 publication(s) in Google Scholar
HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats.
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- CAS No.: 207678-81-7
- Formule: C71H94N20O17S2
- Masse moléculaire:1563.76
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) HS014
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Activité biologique
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MC4R |
Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 207678-81-7
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Masse moléculaire 1563.76
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Formule C71H94N20O17S2
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Sequence
Ac-Cys-Glu-His-{D-2Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Cys1-Cys8)
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Sequence Shortening
Ac-CEH-{D-2Nal}-RWGCPPKD-NH2 (Disulfide bridge:Cys1-Cys8)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice. [Abstract]2025 Jul;46(7):1892-1904. PMID: 40011629
Pureté et documentation
Références
[1]. Schiöth HB,et al. Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol. 1998;124(1):75-82. [Content Brief]
[2]. Ercil NE, et al. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Psychopharmacology (Berl). 2005;180(2):279-285. [Content Brief]
[3]. Kask A, et al. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun. 1998;245(1):90-93. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HS014 Related Classifications
HY-P1216 Related Classifications
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