Indisulam (Standard)
Indisulam (Standard) (E 7070 (Standard)) is the analytical standard of Indisulam (HY-13650). This product is intended for research and analytical applications. Indisulam (E 7070) is a carbonic anhydrase inhibitor and RBM39 molecular glue degrader, with Ki values of 31, 15, and 24 nM against human carbonic anhydrase I, II, and IX, respectively, and a Ki value of 65 nM against bovine carbonic anhydrase IV. Indisulam promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase complex, triggering polyubiquitination and proteasomal degradation of RBM39. Indisulam induces aberrant pre-mRNA splicing, G1 cell cycle arrest, and cell death in cancer cells. As an anticancer agent, Indisulam drives tumor regression and growth inhibition in xenograft models. Indisulam can be used in research related to solid tumors, hematologic and lymphoid malignancies, colorectal cancer, and non-small cell lung cancer.
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- Pureté : 98%
- CAS No.: 165668-41-7
- Formule: C14H12ClN3O4S2
- Masse moléculaire:385.85
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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HY-13650
IndisulamCarbonic Anhydrase Inhibitor/RBM39 Molecular Glue Degrader -
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TopiramateAntiepileptic Agent -
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Dorzolamide hydrochlorideCarbonic Anhydrase II Inhibitor -
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Acetazolamide (Standard) -
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Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 165668-41-7
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Masse moléculaire 385.85
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Formule C14H12ClN3O4S2
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SMILES
O=S(C1=CC=C(S(=O)(N)=O)C=C1)(NC2=CC=CC3=C2NC=C3Cl)=O
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Synonyms
E 7070 (Standard)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorganic & medicinal chemistry letters. 2004 Jan 05;14(1):217-23. [Content Brief]
[2]. Han T, et al. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.). 2017 Apr 28;356(6336):eaal3755. [Content Brief]
[3]. Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. European journal of cancer (Oxford, England : 1990). 2001 Nov;37(17):2275-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Indisulam (Standard) Related Classifications
HY-13650R Related Classifications
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Keywords
- Indisulam (Standard)
- 165668-41-7
- E 7070 (Standard)
- Reference Standards
- Molecular Glues
- Carbonic Anhydrase
- human carbonic anhydrase I
- CUL4-DCAF15 E3 ubiquitin ligase complex
- human carbonic anhydrase IX
- RBM39
- human carbonic anhydrase IV
- HCT-116 human colorectal carcinoma cells
- non-small cell lung cancer
- hematopoietic and lymphoid malignancies
- human carbonic anhydrase II
- colorectal cancer
- Inhibitor
- inhibitor
- inhibit