Indoramin

Indoramin hydrochloride (10⁻⁸-3 × 10⁻⁷ M; 20 min; rat vas deferens) competitively antagonizes norepinephrine-induced contractions mediated by α_1A-adrenergic receptors, with a pA₂ value of 8.52^[4].
Indoramin hydrochloride exerts an anti-vasoconstrictive effect in the experiment of norepinephrine-induced renal vasoconstriction in isolated perfused rat kidneys, with a −log ED₅₀ (mol) of 9.97 for half-maximal effect^[4].
Indoramin hydrochloride competitively antagonizes norepinephrine-induced contraction mediated by α_1B-adrenergic receptors in guinea pig and mouse spleens, with pA₂ values of 6.83 and 6.69, respectively; the pA₂ value for α_1A-adrenergic receptors in rat vas deferens is 8.52^[4].
Under hypoxic conditions, indoramin mesylate (0.1 mM; rat cerebral cortical slices) increases the ATP synthesis rate from 58 to 92 μmol ATP/g cortex/h, without significantly altering the ATP utilization rate; accordingly, the ATP synthesis/utilisation ratio increases from 0.44 in hypoxic controls to 0.71^[2].
Indoramin mesylate (0.1 mM) attenuates hypoxia-induced swelling of rat brain synaptosomes, reducing the swelling index from 153 to 122; it also partially inhibits the increase in intracellular water content in brain microvascular cells, decreasing the intracellular water volume from 5.1 to 4.0 μL H₂O/mg protein^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.