Jun16229
Jun16229 is a covalent inhibitor of CHIKV nsP2 cysteine protease (IC50 0.27 μM). Jun16229 exhibits anti-CHIKV activity. Jun16229 shows broad-spectrum antiviral activity against ONNV, MAYV, and RRV.
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- Formule: C19H16FN3O4S
- Masse moléculaire:401.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | EC50 |
2.2 μM
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Antiviral activity against CHIKV 181/25 in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 72 hrs by neutral red staining.
Antiviral activity against CHIKV 181/25 in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 72 hrs by neutral red staining.
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42720489 |
| Vero | CC50 |
25.5 μM
|
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red staining.
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red staining.
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42720489 |
| Vero | EC50 |
0.93 μM
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Inhibition of CHIKV plaque formation in african green monkey Vero cells incubated for 72 hrs by crystal violet staining.
Inhibition of CHIKV plaque formation in african green monkey Vero cells incubated for 72 hrs by crystal violet staining.
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42720489 |
| Vero | EC50 |
0.94 μM
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Antiviral activity against ONNV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
Antiviral activity against ONNV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
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42720489 |
| Vero | EC50 |
0.56 μM
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Antiviral activity against MAYV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
Antiviral activity against MAYV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
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42720489 |
| Vero | EC50 |
0.59 μM
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Antiviral activity against RRV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
Antiviral activity against RRV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
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42720489 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 401.41
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Formule C19H16FN3O4S
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SMILES
CS(=O)(/C=C/CNC(C1=CC(C2=NOC(C3=C(C=CC=C3)F)=N2)=CC=C1)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Jun16229 Related Classifications
HY-189432 Related Classifications
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