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Cat. No.: HY-18612

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MK-7725

MK-7725 is a selective, orally active, and blood-brain barrier-permeable agonist of the subtype 3 of the frog skin peptide receptor (BRS-3). MK-7725 has a high affinity for the human BRS-3 (hBRS-3), with an IC₅₀ of 3 nM, and its functional activity in the mouse-derived BRS-3 (mBRS-3) model with an EC₅₀ of 22 nM (105% agonistic). MK-7725 significantly reduces the body weight of obese rats and obese dogs. MK-7725 can be used for the treatment of obesity.

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CAS No.: 1034152-93-6
Formule: C₂₅H₁₉F₆N₅O₅S
Masse moléculaire:615.50

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

MK-7725 Chemical Structure

CAS No.: 1034152-93-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	3.6 nM Compound: 1, MK-7725	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	[PMID: 22494842]
CHO	IC₅₀	3.6 nM Compound: 14, MK-7725	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	[PMID: 24900461]
CHO-K1	EC₅₀	1.4 nM Compound: 2, MK-7725	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	[PMID: 24412111]
CHO-K1	EC₅₀	130 nM Compound: 1b, MK-7725	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	[PMID: 25497965]
CHO-K1	EC₅₀	22 nM Compound: 2, MK-7725	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	[PMID: 24412111]
CHO-K1	EC₅₀	73 nM Compound: 1b, MK-7725	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	[PMID: 25497965]

Chemical Information

CAS No. 1034152-93-6
Masse moléculaire 615.50
Formule C₂₅H₁₉F₆N₅O₅S
SMILES

O=S(C1=CC=C(C=C1)OC(F)(F)F)(N2C3=C(C4=NOC(C(C)(C)O)=N4)C=CC=C3NC5=NC(C(F)(F)F)=CC=C5C2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chobanian HR, et al. Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett. 2012 Jan 21;3(3):252-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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