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Cat. No.: HY-W650803

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Nemazoline

(Synonyms: A-57219 free base; SCH 40054 free base)

Nemazoline (A-57219) is selective α-adrenergic agent with α₁-agonist/α₂-antagonist activity, which is used as a nasal decongestant. Nemazoline produces decongestion by α₁-mediated contraction of capacitance vessels, but not compromises blood flow by virtue of α₂-antagonism. Nemazoline also blocks endogenous noradrenaline-mediated α ₂-constriction of the resistance vessels.

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CAS No.: 130759-56-7
Formule: C₁₀H₁₁Cl₂N₃
Masse moléculaire:244.12

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Nemazoline Chemical Structure

CAS No.: 130759-56-7

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Sample (0.1mg)

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(In Japan)

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Bioz

Activité biologique

Description

IC₅₀ & Target

α1-adrenergic receptor

α2-adrenergic receptor

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Chemical Information

CAS No. 130759-56-7
Masse moléculaire 244.12
Formule C₁₀H₁₁Cl₂N₃
SMILES

NC1=C(C=C(C=C1Cl)CC2=NCCN2)Cl
Synonyms

A-57219 free base; SCH 40054 free base
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. DeBernardis JF, et al. A new nasal decongestant, A-57219: a comparison with oxymetazoline. J Pharm Pharmacol. 1987 Sep;39(9):760-3. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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