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Cat. No.: HY-149043

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NIK-IN-1

NIK-IN-1 (Compound 2) is an inhibitor of NF-κB-inducing kinase (NIK). NIK-IN-1 is used for research on hepatic inflammatory diseases and acute liver injury.

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CAS No.: 1451079-18-7
Formule: C₂₂H₂₁N₅O₅
Masse moléculaire:435.43

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

NIK-IN-1 Chemical Structure

CAS No.: 1451079-18-7

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

NIK-IN-1 (Compound 2) is an inhibitor of NF-κB-inducing kinase (NIK). NIK-IN-1 is used for research on hepatic inflammatory diseases and acute liver injury^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	13 μM Compound: 33	Cytotoxicity against HEK293 cells assessed as effect on cell viability after 24 hrs by HSV-TK reporter assay Cytotoxicity against HEK293 cells assessed as effect on cell viability after 24 hrs by HSV-TK reporter assay	[PMID: 28005357]
HeLa	IC₅₀	>20 μM Compound: 33	Inhibition of TNF-alpha-stimulated RELA translocation from cytoplasm to nucleus in human HeLa cells preincubated for 4.5 hrs followed by TNF-alpha stimulation measured after 30 mins Inhibition of TNF-alpha-stimulated RELA translocation from cytoplasm to nucleus in human HeLa cells preincubated for 4.5 hrs followed by TNF-alpha stimulation measured after 30 mins	[PMID: 28005357]
HeLa	IC₅₀	67 nM Compound: 33	Inhibition of NIK in human HeLa cells assessed as decrease in antilymphotoxin-beta receptor antibody-stimulated p52 translocation from cytoplasm to nucleus after 5 hrs Inhibition of NIK in human HeLa cells assessed as decrease in antilymphotoxin-beta receptor antibody-stimulated p52 translocation from cytoplasm to nucleus after 5 hrs	[PMID: 28005357]

Chemical Information

CAS No. 1451079-18-7
Masse moléculaire 435.43
Formule C₂₂H₂₁N₅O₅
SMILES

O=C(C1=C(C(NC)=O)N2CCOC3=CC=C(C#C[C@](C4=NOC(C)=C4)(O)C)C=C3C2=N1)N
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li Z, et al. Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo. J Med Chem. 2020;63(8):4388-4407. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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NIK-IN-1

Voir tous les produits spécifiques à Isoform NF-κB

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

NIK-IN-1 Related Classifications

HY-149043 Related Classifications