NP-184
NP-184 is a novel orally active antithrombotic agent. NP-184 selectively inhibits TXA2 synthase activity with an IC50 value of 4.3 μM. NP-184 has antiplatelet and antithrombotic activities. NP-184 can be used in the research of thromboembolic diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 78706-11-3
- Formule: C12H10N2O
- Masse moléculaire:198.22
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Activité biologique
Description
IC50 & Target
IC50: 4.3 μM (TXA2 synthase)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
102.54 μM
Compound: 4b
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
|
[PMID: 28505536] |
| MCF7 | IC50 |
14 μg/mL
Compound: 3b
|
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 24576797] |
| MCF7 | IC50 |
55.55 μM
Compound: 4b
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
|
[PMID: 28505536] |
Chemical Information
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CAS No. 78706-11-3
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Appearance Solid
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Masse moléculaire 198.22
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Formule C12H10N2O
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Color Light brown to brown
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SMILES
CC1=CC=C(C2=NC3=CC=CC=C3N2)O1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)