NSC309401
NSC309401 is an inhibitor of E. coli DHFR (IC50: 189 nM, KD: 14.57 nM).
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- CAS No.: 750522-61-3
- Formule: C17H16N6
- Masse moléculaire:304.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
189 nM (E. coli DHFR)[1].
Chemical Information
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CAS No. 750522-61-3
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Masse moléculaire 304.35
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Formule C17H16N6
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SMILES
NC(C=C1)=CC=C1CN2C=CC3=C4C(N=C(N)N=C4N)=CC=C32
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
[1]. Srinivasan B, et al. Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors. FEBS J. 2015 May;282(10):1922-38. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NSC309401 Related Classifications
HY-156859A Related Classifications
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