ORG 30276
ORG 30276 (APTAA-LHRH) is a potent GnRH antagonist that effectively reduces serum LH and FSH levels in male rats. ORG 30276 significantly decreases unoccupied pituitary GnRH receptors, leading to suppressed gonadotropin secretion. ORG 30276 treatment results in a considerable reduction in mRNA levels of gonadotropin beta-subunits in the pituitary gland. ORG 30276's effects on gonadotropin dynamics can be selectively reversed by the replacement of specific sex steroids, with androgens being particularly effective for the FSH beta-subunit mRNA levels.
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- CAS No.: 83539-08-6
- Formule: C69H91Cl2N17O14
- Masse moléculaire:1453.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
Chemical Information
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CAS No. 83539-08-6
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Masse moléculaire 1453.47
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Formule C69H91Cl2N17O14
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Synonyms
APTAA-LHRH
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Sequence
Ac-{d-Phe(4-Cl)}-{d-Phe(4-Cl)}-{d-Trp}-Ser-Tyr-{d-Arg}-Leu-Arg-Pro-{d-Ala}
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Sequence Shortening
Ac-{d-Phe(4-Cl)}-{d-Phe(4-Cl)}-{d-Trp}SY-{d-Arg}-LRP-{d-Ala}
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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