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Cat. No.: HY-183623

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ProAlk01

ProAlk01 is a protein alkylating agent that serves as a toxin payload for ADCs. ProAlk01 localizes to the cytoplasm and exerts cytotoxic effects mainly by alkylating cytoplasmic proteins rather than binding to DNA. ProAlk01 induces cell cycle arrest, apoptosis, and immunogenic cell death. ProAlk01 can be used in the research of solid tumors.

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CAS No.: 1296670-84-2
Formule: C₃₁H₂₈Cl₂N₂O₄
Masse moléculaire:563.47

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ProAlk01 Chemical Structure

CAS No.: 1296670-84-2

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform ADC Payloads :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.7 nM Compound: BDA 2	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 30620194]

In Vitro

ProAlk01 (1-100 pM) exhibits potent in vitro cytotoxic activity across a broad panel of solid tumor cell lines with IC₅₀ values in the 1-100 pM range^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1296670-84-2
Masse moléculaire 563.47
Formule C₃₁H₂₈Cl₂N₂O₄
SMILES

O=C(N1C[C@H](C2=C1C=C(C3=C2C=CC=C3)O)CCl)CCCC(N4C[C@H](C5=C4C=C(C6=C5C=CC=C6)O)CCl)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Turska A, et al. PA289: A first-in-class prodrug payload with a novel mechanism of action and favorable efficacy/safety profile. Cancer Research. 2026 Apr 3;86(7_Supplement):1712-.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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ProAlk01

Voir tous les produits spécifiques à Isoform ADC Payloads

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

ProAlk01 Related Classifications

HY-183623 Related Classifications