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Cat. No.: HY-149297

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PSMA-IN-1

PSMA-IN-1 (compound 23) is an inhibitor of PSMA with a K_i value of 2.49 nM. PSMA-IN-1 inhibits tumor growth with high selectivity and specificity in PSMA+ xenograft models. PSMA-IN-1 is a NIR probe (λ_EX: 620 nm; λ_EM: 670 nm) used for tumor disappearance. PSMA-IN-1 can be used for research on prostate cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₆₆H₈₀N₁₀O₂₀
Masse moléculaire:1333.40

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

PSMA-IN-1 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

In Vivo

PSMA-IN-1 (0.33 mg/kg, i.v., one time) is a NIR probe (λ_EX: 620 nm; λ_EM: 670 nm) used for tumor disappearance, and acquires images at different time points after injection(2, 4, 8, 12, 24, and 48 h) ^[1].
PSMA-IN-1 (0.33 mg/kg, i.v., one time) inhibits tumor growth with high selectivity and specificity in the BALB/C nude mice tumor bearing model constructed with 22Rv1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

22Rv1 xenograft models in BALB/C nude mice^[1]
Dosage:

0.33 mg/kg
Administration:

Intravenous injection (i.v.), sacrificed at 55 h post-injection
Result:

Increased TNR (tumor-to-normal tissue ratio) values from 3.20 at 2 h to 6.27 at 48 h.

Related Protocols :

Chemical Information

Masse moléculaire 1333.40
Formule C₆₆H₈₀N₁₀O₂₀
SMILES

OC(C1=O)=C(NC[C@H](NC(N[C@@H](CCCCNC(CCCCC[N+]2=C(C(C)(C3=C2C=CC=C3)C)/C=C4C([O-])=C(C\4=O)/C=C5C(C)(C6=C(N/5CCCCCC(NCCCC[C@H](NC(N[C@H](C(O)=O)CNC(C7=O)=C(C7=O)O)=O)C(O)=O)=O)C=CC=C6)C)=O)C(O)=O)=O)C(O)=O)C1=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang X, et al. Design and Characterization of Squaramic Acid-Based Prostate-Specific Membrane Antigen Inhibitors for Prostate Cancer. J Med Chem. 2023 May 25;66(10):6889-6904. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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