Rpi-856 A
Rpi-856 A is a competitive inhibitor of HIV-1 protease and HTLV-I protease, with an IC50 of 37 nM against HIV-1 protease and an IC50 of 27 nM against HTLV-I protease. Rpi-856 A inhibits Pepsin with an IC50 of 1.9 μM. Rpi-856 A does not inhibit chymosin, trypsin, chymotrypsin, papain, bromelain, thermolysin, prolyl endopeptidase, carboxypeptidase A or carboxypeptidase B. Rpi-856 A can be used in the research of acquired immunodeficiency syndrome (AIDS) and related diseases, as well as HIV infection.
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- CAS No.: 157381-54-9
- Formule: C43H61N7O13
- Masse moléculaire:883.98
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
Rpi-856 A (3 h) competitively inhibits recombinant HIV-1 protease (expressed in Escherichia coli MM294 (DE3)/pHIV7004), with a Ki of 13 nM and an IC50 of 37 nM[1].
Rpi-856 A (3 h) competitively inhibits recombinant HTLV-I protease (expressed in Escherichia coli MM294 (DE3)/pHTI7707) with an IC50 of 27 nM[1].
Rpi-856 potently inhibits HIV-1 protease in cell-free biochemical assays, with an IC50 value of 37 nM[2].
Rpi-856 A inhibits porcine pepsin with an IC50 of 1.9 μM, and its activity is weaker than that against retroviral protease[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 157381-54-9
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Masse moléculaire 883.98
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Formule C43H61N7O13
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Sequence
Val-{Gly(2-(3,5-dihydroxyphenyl))}-Leu-{2-oxo-4-phenyl-3-aminobutanoyl}-Val-Val-Asp
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Sequence Shortening
V-{Gly(2-(3,5-dihydroxyphenyl))}-L-{2-oxo-4-phenyl-3-aminobutanoic acid}-VVD
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rpi-856 A Related Classifications
HY-P1981 Related Classifications
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