Thalidomide-O-PEG4-azide
Based on 1 publication(s) in Google Scholar
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- Pureté : 98.02%
- CAS No.: 2380318-57-8
- Formule: C23H29N5O9
- Masse moléculaire:519.50
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Thalidomide-O-PEG4-azide
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Activité biologique
Description
IC50 & Target
[1]|
Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2380318-57-8
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Appearance Oil
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Masse moléculaire 519.50
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Formule C23H29N5O9
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Color Colorless to light yellow
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCN=[N+]=[N-])=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Rep Med
Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer. [Abstract]2026 May 19;7(5):102763. PMID: 42030934
Solvant et solubilité
In Vitro:
DMSO : 250 mg/mL (481.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9249 mL | 9.6246 mL | 19.2493 mL | 48.1232 mL |
| 5 mM | 0.3850 mL | 1.9249 mL | 3.8499 mL | 9.6246 mL | |
| 10 mM | 0.1925 mL | 0.9625 mL | 1.9249 mL | 4.8123 mL | |
| 15 mM | 0.1283 mL | 0.6416 mL | 1.2833 mL | 3.2082 mL | |
| 20 mM | 0.0962 mL | 0.4812 mL | 0.9625 mL | 2.4062 mL | |
| 25 mM | 0.0770 mL | 0.3850 mL | 0.7700 mL | 1.9249 mL | |
| 30 mM | 0.0642 mL | 0.3208 mL | 0.6416 mL | 1.6041 mL | |
| 40 mM | 0.0481 mL | 0.2406 mL | 0.4812 mL | 1.2031 mL | |
| 50 mM | 0.0385 mL | 0.1925 mL | 0.3850 mL | 0.9625 mL | |
| 60 mM | 0.0321 mL | 0.1604 mL | 0.3208 mL | 0.8021 mL | |
| 80 mM | 0.0241 mL | 0.1203 mL | 0.2406 mL | 0.6015 mL | |
| 100 mM | 0.0192 mL | 0.0962 mL | 0.1925 mL | 0.4812 mL |
Thalidomide-O-PEG4-azide Related Classifications
HY-140844 Related Classifications
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