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Cat. No.: HY-162163

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TLR7 agonist 19

TLR7 agonist 19 (Compound 14) is a Toll-like receptor 7 (TLR7) agonist with excellent pharmacokinetic properties and synergistic antitumor activity.

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CAS No.: 2682008-42-8
Formule: C₂₈H₄₂N₈O₃
Masse moléculaire:538.68

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

TLR7 agonist 19 Chemical Structure

CAS No.: 2682008-42-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

TLR7 agonist 19 (Compound 14) is a Toll-like receptor 7 (TLR7) agonist with excellent pharmacokinetic properties and synergistic antitumor activity.

Voir tous les produits spécifiques à Isoform Toll-like Receptor (TLR) :

Cellular Effect

Cell Line	Type	Value	Description	References
T-cell	IC₅₀	>25 μM Compound: 14	Cytotoxicity against PHA-activated T-cells (unknown origin) assessed as inhibition of IL-2 induced cell proliferation measured after 72 hrs by MTS assay Cytotoxicity against PHA-activated T-cells (unknown origin) assessed as inhibition of IL-2 induced cell proliferation measured after 72 hrs by MTS assay	[PMID: 38352849]

Chemical Information

CAS No. 2682008-42-8
Masse moléculaire 538.68
Formule C₂₈H₄₂N₈O₃
SMILES

CCC[C@H](NC1=C(N(CC2=NC=C(C3CCN(C4CCOCC4)CC3)C=C2OC)N=C5)C5=NC(N)=N1)CCO
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. He L, et al. Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology[J]. ACS Medicinal Chemistry Letters, 2024.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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TLR7 agonist 19

Voir tous les produits spécifiques à Isoform Toll-like Receptor (TLR)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

TLR7 agonist 19 Related Classifications

HY-162163 Related Classifications