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Cat. No.: HY-189255

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TrkB-IN-2

TrkB-IN-2 is a TrkB inhibitor. TrkB-IN-2 exhibits anticancer activity against neuroblastoma. TrkB-IN-2 can be used for research on neuroblastoma.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₄H₂₁FN₄O₆S
Masse moléculaire:512.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TrkB-IN-2 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

TrkB-IN-2 is a TrkB inhibitor. TrkB-IN-2 exhibits anticancer activity against neuroblastoma. TrkB-IN-2 can be used for research on neuroblastoma^[1].

IC₅₀ & Target

^[1]

TrkB

Voir tous les produits spécifiques à Isoform Trk Receptor :

In Vitro

TrkB-IN-2 (500 nM; 30 min) is among the most effective compounds at suppressing BDNF-induced TrkB phosphorylation in ECP007 cells^[1].
TrkB-IN-2 (100-10000 nM; 30 min) effectively suppresses BDNF-induced TrkB phosphorylation in ECP007 cells in a dose-dependent manner^[1].
TrkB-IN-2 (0.005-100 μM; 72 h) inhibits the growth of COG-N-549 neuroblastoma cells and exhibits cytostatic effects on CUTO-3 cells at concentrations under 10,000 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

ECP007
Concentration:

500 nM
Incubation Time:

30 min
Result:

Showed the greatest decrease in the ratio of phosphorylated TrkB to total TrkB.

ELISA Assay^[1]

Cell Line:

ECP007
Concentration:

100-10000 nM
Incubation Time:

30 min
Result:

Showed the greatest decrease in the ratio of phosphorylated TrkB to total TrkB.

Cell Viability Assay^[1]

Cell Line:

COG-N-549, ECP005, ECP007, CUTO-3
Concentration:

0.005-100 μM
Incubation Time:

72 h
Result:

Showed growth inhibition in COG-N-549 cells.
Showed cytostatic growth inhibition in CUTO-3 cells at concentrations under 10,000 nM.

Chemical Information

Masse moléculaire 512.51
Formule C₂₄H₂₁FN₄O₆S
SMILES

COC1=CC(C2=NN=C(N2C3=CC=CC=C3)S(=O)(CC(NC4=CC(F)=CC=C4OC)=O)=O)=CC=C1O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Rasmussen S V, et al. Allosteric Inhibition of TrkB Activation as Related to Neuroblastoma by Triazole Bridged Compounds[J]. ACS Chemical Biology, 2026.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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TrkB-IN-2

Voir tous les produits spécifiques à Isoform Trk Receptor

Activité biologique

Description

IC50 & Target

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

TrkB-IN-2 Related Classifications

HY-189255 Related Classifications

Bioz

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