U-99194
U-99194 (PNU-99194) is a selective, potent dopamine D3 receptor antagonist. U-99194 inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 significantly suppresses Nicotine (HY-127019)-induced tremor in mice. U-99194 can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors.
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- CAS No.: 82668-33-5
- Formule: C17H27NO2
- Masse moléculaire:277.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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D3 Receptor |
U-99194 (1 μM, 15 min) prevents the cocaine-induced inhibition of monosynaptic inhibitory postsynaptic currents (IPSCs) evoked from stratum radiatum in CA1 pyramidal neurons of rat hippocampal slices[2].
U-99194 (1 μM) blocks the inhibitory effect of PD 128907 ( HY-100539) on the amplitude of monosynaptic IPSCs evoked from stratum radiatum in CA1 pyramidal neurons of rat hippocampal slices[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
U-99194 (30 μg/site, intracerebellar microinjection, once) markedly inhibits Nicotine-induced tremor in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nicotine (1 mg/kg, i.p.) was injected to induce kinetic tremor in male ddY mice (7-11 weeks of age)[1]
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Dosage:30 mg/kg
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Administration:i.p., once
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Result:Suppressed Nicotine (HY-127019)-induced tremor.
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Animal Model:Nicotine (1 mg/kg, i.p.) was injected to induce kinetic tremor in Male SD rats (7-11 weeks of age)[1]
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Dosage:30 μg/site
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Administration:intracerebellar microinjection, once
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Result:Suppressed Nicotine (HY-127019)-induced tremor.
Chemical Information
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CAS No. 82668-33-5
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Masse moléculaire 277.40
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Formule C17H27NO2
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SMILES
CCCN(CCC)C1CC2=C(C=C(OC)C(OC)=C2)C1
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Synonyms
U-99194A free base; PNU-99194A; JPC-211
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Kato M, et al. Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Front Pharmacol. 2022 Jun 16;13:938175. [Content Brief]
[2]. Hammad H, et al. Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation. J Pharmacol Exp Ther. 2006 Jan;316(1):113-20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
U-99194 Related Classifications
HY-12701 Related Classifications
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