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  6. Calanolide A

Calanolide A is an antioxidant that was initially thought to be produced by neuroblastoma cells but was later detected as a contaminant in the cell culture medium with no clear biological activity.

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Calanolide A

Calanolide A Chemical Structure

CAS No. : 142632-32-4

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Calanolide A Related Antibodies

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Description

Calanolide A is an antioxidant that was initially thought to be produced by neuroblastoma cells but was later detected as a contaminant in the cell culture medium with no clear biological activity.

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM EC50
0.267 μM
Compound: (+)-1
Anti-HIV activity against HIV-I RFII strain in CEM cell line
Anti-HIV activity against HIV-I RFII strain in CEM cell line
[PMID: 8632437]
CCRF-CEM IC50
22.96 μM
Compound: (+)-1
Anti-HIV activity against HIV-I RFII strain in CEM cell line
Anti-HIV activity against HIV-I RFII strain in CEM cell line
[PMID: 8632437]
CEM-SS EC50
0.08 μM
Compound: 1
Inhibition of HIV-1 replication in CEM-SS human lymphoblastoid cells in vitro
Inhibition of HIV-1 replication in CEM-SS human lymphoblastoid cells in vitro
[PMID: 1379639]
CEM-SS EC50
0.1 μM
Compound: 1
Potency to inhibit HIV-1 induced cytopathic effects in human T-lymphoblastic cells(CEM-SS) and essentially halted HIV-1 replication.
Potency to inhibit HIV-1 induced cytopathic effects in human T-lymphoblastic cells(CEM-SS) and essentially halted HIV-1 replication.
[PMID: 1379639]
CEM-SS EC50
0.14 μM
Compound: (+)-Calanolide A
Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells
Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells
[PMID: 9873509]
CEM-SS EC50
0.17 μM
Compound: (+)-Calanolide A
Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells
Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells
[PMID: 9873509]
CEM-SS EC50
0.18 μM
Compound: 1
Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
[PMID: 8893846]
CEM-SS EC50
0.2 μM
Compound: (+)-Calanolide A
Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect
Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect
[PMID: 11430019]
CEM-SS EC50
0.27 μM
Compound: (+)-Calanolide A
Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells
Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells
[PMID: 9873509]
CEM-SS EC50
0.27 μM
Compound: (+)7
Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined
Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined
[PMID: 9083491]
CEM-SS EC50
0.49 μM
Compound: (+/-) 7
Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined
Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined
[PMID: 9083491]
CEM-SS ED50
0.31 μM
Compound: calanolide A
Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect after 6 days by MTS assay
Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect after 6 days by MTS assay
[PMID: 15217281]
CEM-SS IC50
20 μM
Compound: 1
Concentration inhibiting HIV-1 induced cytopathic effects in human T-lymphoblastic cells(CEM-SS) and essentially halted HIV-1 replication.
Concentration inhibiting HIV-1 induced cytopathic effects in human T-lymphoblastic cells(CEM-SS) and essentially halted HIV-1 replication.
[PMID: 1379639]
CEM-SS IC50
23 μM
Compound: (+)7
Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls
Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls
[PMID: 9083491]
CEM-SS IC50
23 μM
Compound: (+/-) 7
Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls
Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls
[PMID: 9083491]
CEM-SS IC50
7.3 μM
Compound: 1
Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
[PMID: 8893846]
MT2 EC50
0.027 μM
Compound: (+)-1
Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line
Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line
[PMID: 8632437]
MT2 EC50
0.053 μM
Compound: (+)-1
Anti-HIV activity against HIV-I IIIB strain in MT2 cell line
Anti-HIV activity against HIV-I IIIB strain in MT2 cell line
[PMID: 8632437]
MT2 EC50
0.107 μM
Compound: (+)-1
Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line
Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line
[PMID: 8632437]
MT2 EC50
0.427 μM
Compound: (+)-1
Anti-HIV activity against HIV-I A17 strain in MT2 cell line
Anti-HIV activity against HIV-I A17 strain in MT2 cell line
[PMID: 8632437]
MT2 IC50
14.8 μM
Compound: (+)-1
Anti-HIV activity against HIV-I IIIB strain in MT2 cell line
Anti-HIV activity against HIV-I IIIB strain in MT2 cell line
[PMID: 8632437]
MT2 IC50
6.99 μM
Compound: (+)-1
Anti-HIV activity against HIV-I A17 strain in MT2 cell line
Anti-HIV activity against HIV-I A17 strain in MT2 cell line
[PMID: 8632437]
MT2 IC50
7.15 μM
Compound: (+)-1
Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line
Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line
[PMID: 8632437]
MT2 IC50
7.17 μM
Compound: (+)-1
Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line
Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line
[PMID: 8632437]
Raji IC50
290 molar ratio
Compound: 1
Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation after 48 hrs relative to control
Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation after 48 hrs relative to control
[PMID: 12662094]
Clinical Trial
Molecular Weight

370.44

Formula

C22H26O5
CAS No.
SMILES

CCCC(C1=C(O2)C3=C(O[C@@H]([C@H]([C@@H]3O)C)C)C4=C1OC(C)(C=C4)C)=CC2=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Calanolide A Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Calanolide A142632-32-4OthersInhibitorinhibitorinhibit

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Calanolide A
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HY-116791
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