1026249-18-2
1026249-18-2
Chemical Structure
CL097
- CAS No.: 1026249-18-2
- Formula:C13H14N4O
- Molecular Weight:242.28
IUPAC Name: 2-(ethoxymethyl)-3H-imidazo[4,5-c]quinolin-4-amine
InChIKey: DEVCLHVFELRPIU-UHFFFAOYSA-N
SMILES: NC1=NC2=CC=CC=C2C3=C1NC(COCC)=N3
Biological Activity: CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages[1]. CL097 induces NADPH oxidase priming, resulting in an increase of the fMLF-stimulated ROS production[2].
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CL097 | 99.90% | CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages. CL097 induces NADPH oxidase priming, resulting in an increase of the fMLF-stimulated ROS production. | ||||||||||||||||||||
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CL097 (Standard) | ≥98% | CL097 (Standard) is the analytical standard of CL097. This product is intended for research and analytical applications. CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages. CL097 induces NADPH oxidase priming, resulting in an increase of the fMLF-stimulated ROS production. | ||||||||||||||||||||
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References
- [1]. Cindy Patinote, et al. Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes. Eur J Med Chem. 2020 May 1;193:112238. [Content Brief]
- [2]. Karama Makni-Maalej, et al. The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1. J Immunol. 2012 Nov 1;18 [Content Brief]
