104713-75-9
Chemical Structure
Barnidipine
Synonym(s): Mepirodipine; YM-09730-5 Free base
- CAS No.: 104713-75-9
- Formula:C27H29N3O6
- Molecular Weight:491.54
IUPAC Name: 3-((S)-1-benzylpyrrolidin-3-yl) 5-methyl (S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey: VXMOONUMYLCFJD-DHLKQENFSA-N
SMILES: O=C(C1=C(C)NC(C)=C(C(O[C@@H]2CN(CC3=CC=CC=C3)CC2)=O)[C@H]1C4=CC=CC([N+]([O-])=O)=C4)OC
Biological Activity: Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki = 0.21 nmol/L), has selective action against CaA receptors. Barnidipine is an orally effective antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance[1][2][3].
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Barnidipine | Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki = 0.21 nmol/L), has selective action against CaA receptors. Barnidipine is an orally effective antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance. | |||||||||||||||||||||
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Barnidipine-d5 | 98.97% | Barnidipine-d5 is the deuterium-labeled Barnidipine (HY-107322A). Barnidipine-d5 (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors. Barnidipine-d5 (Mepirodipine) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action. | ||||||||||||||||||||
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References
- [1]. van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8 [Content Brief]
- [2]. Malhotra HS, et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8. [Content Brief]
- [3]. Hashimoto M, et al. Treatment with a Ca(2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats. Am J Nephrol. 1999;19(5):615-21. [Content Brief]
