108605-70-5
Chemical Structure
Avenanthramide A
- CAS 番号: 108605-70-5
- Formula:C16H13NO5
- Molecular Weight:299.28
IUPAC Name: (E)-5-hydroxy-2-(3-(4-hydroxyphenyl)acrylamido)benzoic acid
InChIKey: QGUMNWHANDITDB-FPYGCLRLSA-N
SMILES: O=C(C1=CC(O)=CC=C1NC(/C=C/C2=CC=C(C=C2)O)=O)O
Biological Activity: Avenanthramide A is an orally active phytoalexin that targets the RNA helicase DDX3 with a KD of 8.8 μM. Avenanthramide A induces mitochondrial swelling and increased ROS production, and triggers apoptosis in CRC cells. Avenanthramide A inhibits smooth muscle cell proliferation and enhances nitric oxide production. Avenanthramide A can be used in research on colorectal cancer and atherosclerosis[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Avenanthramide A | 98.35% | Avenanthramide A is an orally active phytoalexin that targets the RNA helicase DDX3 with a KD of 8.8 μM. Avenanthramide A induces mitochondrial swelling and increased ROS production, and triggers apoptosis in CRC cells. Avenanthramide A inhibits smooth muscle cell proliferation and enhances nitric oxide production. Avenanthramide A can be used in research on colorectal cancer and atherosclerosis. | ||||||||||||||||||||
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Avenanthramide A (Standard) | ≥98% | Avenanthramide A (Standard) is the analytical standard of Avenanthramide A. This product is intended for research and analytical applications. Avenanthramide A is an orally active phytoalexin that targets the RNA helicase DDX3 with a KD of 8.8 μM. Avenanthramide A induces mitochondrial swelling and increased ROS production, and triggers apoptosis in CRC cells. Avenanthramide A inhibits smooth muscle cell proliferation and enhances nitric oxide production. Avenanthramide A can be used in research on colorectal cancer and atherosclerosis. | ||||||||||||||||||||
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Avenanthramide A-d4 | Avenanthramide A-d4 is the deuterium labeled Avenanthramide A (HY-114977). Avenanthramide A is an orally active phytoalexin that targets the RNA helicase DDX3 with a KD of 8.8 μM. Avenanthramide A induces mitochondrial swelling and increased ROS production, and triggers apoptosis in CRC cells. Avenanthramide A inhibits smooth muscle cell proliferation and enhances nitric oxide production. Avenanthramide A can be used in research on colorectal cancer and atherosclerosis. | |||||||||||||||||||||
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Similarity Score 0.90
HY-N18069Avenanthramide L -
Similarity Score 0.86
HY-118693Avenanthramide D -
Similarity Score 0.86
HY-124344Avenanthramide C -
Similarity Score 0.81
HY-N17673Avenanthramide 1c -
Similarity Score 0.80
HY-138284Avenanthramide-C methyl ester -
Similarity Score 0.77
HY-126734Avenanthramide E -
Similarity Score 0.77
HY-181140UNPD139734 -
Similarity Score 0.74
HY-18706trans-Tranilast -
Similarity Score 0.74
HY-B0195RTranilast (Standard) -
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References
- [1]. Fu R, et al. Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3. Cell Death Dis. 2019;10(8):593. Published 2019 Aug 7. [Content Brief]
- [2]. Nie L, et al. Avenanthramide, a polyphenol from oats, inhibits vascular smooth muscle cell proliferation and enhances nitric oxide production. Atherosclerosis. 2006;186(2):260-266. [Content Brief]
