11076-67-8
11076-67-8
Chemical Structure
Penitrem B
Synonym(s): Tremortin B
- CAS No.: 11076-67-8
- Formula:C37H45NO5
- Molecular Weight:583.76
InChIKey: CRPJNVUYZRFGAK-XAQUJXFWSA-N
SMILES: O[C@]12[C@]34[C@]([C@H]([C@H](O[C@]4([H])CC[C@@]1([C@]5(C6=C7[C@](OC(C)([C@]8([H])[C@@]9([H])C%10=C7C(N6)=CC=C%10CC([C@@]9([H])C8)=C)C)([H])[C@]5([H])CC2)C)C)C(C)=C)O)([H])O3
Biological Activity: Penitrem B (Tremortin B) is a dechlorinated indole diterpene tremorgen found in fungi such as Penicillium palitans and Aspergillus sulphureus. Penitrem B induces tremors, ataxia, and convulsions in mice. Penitrem B is used in research related to tremogenic mycotoxicosis and fungal infections[1][2][3][4].
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Penitrem B | Penitrem B (Tremortin B) is a dechlorinated indole diterpene tremorgen found in fungi such as Penicillium palitans and Aspergillus sulphureus. Penitrem B induces tremors, ataxia, and convulsions in mice. Penitrem B is used in research related to tremogenic mycotoxicosis and fungal infections. | |||||||||||||||||||||
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References
- [1]. Gao SS, et al. Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189. J Nat Prod. 2016 Aug 26;79(8):2066-74. [Content Brief]
- [2]. Hou CT, et al. Tremorgenic toxins from penicillia. II. A new tremorgenic toxin, tremortin B, from Penicillium palitans. Can J Microbiol. 1971 May;17(5):599-603.
- [3]. Laakso J A, et al. A new penitrem analog with antiinsectan activity from the sclerotia of Aspergillus sulphureus[J]. Journal of agricultural and food chemistry, 1993, 41(6): 973-975.
- [4]. Moldes-Anaya A, et al. Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice. Toxicon : official journal of the International Society on Toxinology. 2012 Dec 15;60(8):1428-35. [Content Brief]
