1133206-74-2
1133206-74-2
Chemical Structure
NVP-BEZ 235-d3
- CAS No.: 1133206-74-2
- Formula:C30H20D3N5O
- Molecular Weight:472.56
IUPAC Name: 2-methyl-2-(4-(3-(methyl-d3)-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
InChIKey: JOGKUKXHTYWRGZ-HPRDVNIFSA-N
SMILES: O=C1N(C=2C=3C(N=CC2N1C([2H])([2H])[2H])=CC=C(C3)C4=CC5=C(N=C4)C=CC=C5)C6=CC=C(C(C#N)(C)C)C=C6
Biological Activity: NVP-BEZ 235-d3 is the deuterium labeled NVP-BEZ 235[1].
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NVP-BEZ 235-d3 | NVP-BEZ 235-d3 is the deuterium labeled NVP-BEZ 235. | |||||||||||||||||||||
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Dactolisib | 99.94% | Dactolisib (BEZ235) is an orally active and dual pan-class I PI3K and mTOR kinase inhibitor with IC50s of 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR, respectively. Dactolisib (BEZ235) inhibits both mTORC1 and mTORC2. | ||||||||||||||||||||
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References
Keywords
