115035-46-6
115035-46-6
Chemical Structure
Gly-Pro-AMC hydrobromide
- CAS No.: 115035-46-6
- Formula:C17H20BrN3O4
- Molecular Weight:410.27
IUPAC Name: (S)-1-glycyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)pyrrolidine-2-carboxamide hydrobromide
InChIKey: PASXTQMFJRHMLJ-ZOWNYOTGSA-N
SMILES: O=C(NC1=CC=C(C(O2)=C1)C(C)=CC2=O)[C@H]3N(C(CN)=O)CCC3.[H]Br
Biological Activity: Gly-Pro-AMC hydrobromide is a fluorescent dipeptide substrate that releases AMC (7-Amino-4-methylcoumarin) (HY-D0027) upon hydrolysis. Gly-Pro-AMC hydrobromide is cleaved by DPP-VII, DPP-II, DPP-IV, X-prolyl dipeptidyl aminopeptidase, DPP9, and FAP to release AMC[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gly-Pro-AMC hydrobromide | 99.81% | Gly-Pro-AMC hydrobromide is a fluorescent dipeptide substrate that releases AMC (7-Amino-4-methylcoumarin) (HY-D0027) upon hydrolysis. Gly-Pro-AMC hydrobromide is cleaved by DPP-VII, DPP-II, DPP-IV, X-prolyl dipeptidyl aminopeptidase, DPP9, and FAP to release AMC. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-137834AGly-Pro-AMC -
Similarity Score 0.81
HY-P4426Lys-Pro-AMC -
Similarity Score 0.79
HY-145983Suc-Gly-Pro-AMC -
Similarity Score 0.78
HY-P4344Met-Gly-Pro-AMC -
Similarity Score 0.74
HY-W436471H-Ala-Pro-AFC -
Similarity Score 0.74
HY-P4448Ac-Gly-Pro-AFC -
Similarity Score 0.72
HY-137859L-Proline 7-amido-4-methylcoumarin hydrobromide -
Similarity Score 0.71
HY-D0991Pro-AMC -
Similarity Score 0.71
HY-D1670Z-Gly-Pro-AMC -
Explore the MedChemAI to find more analogs
References
- [1]. Leiting B, et al. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. The Biochemical journal. 2003 Apr 15;371(Pt 2):525-32. [Content Brief]
- [2]. Kato T, et al. Fluorescence assay of x-prolyl dipeptidyl-aminopeptidase activity with a new fluorogenic substrate. Biochem Med. 1978 Jun;19(3):351-9.
- [3]. Bhattacharjee A, et al. DPP8/9 are not Required to Cleave Most Proline-Containing Peptides. Israel journal of chemistry. 2023 Mar;63(3-4):e202200117.
- [4]. Zhang B, et al. A cell-based fluorescent assay for FAP inhibitor discovery. Bioorganic & medicinal chemistry letters. 2020 Jul 15;30(14):127253. [Content Brief]
- [5]. Tahara A, et al. Antihyperglycemic effects of ASP8497 in streptozotocin-nicotinamide induced diabetic rats: comparison with other dipeptidyl peptidase-IV inhibitors. Pharmacological reports : PR. 2009;61(5):899-908.
