1181081-71-9
Chemical Structure
CLP257
- CAS No.: 1181081-71-9
- Formula:C14H14FN3O2S
- Molecular Weight:307.34
IUPAC Name: (Z)-5-(4-fluoro-2-hydroxybenzylidene)-2-(tetrahydropyridazin-1(2H)-yl)thiazol-4(5H)-one
InChIKey: SKCADXVKQRCWTR-GHXNOFRVSA-N
SMILES: O=C1N=C(N2CCCCN2)S/C1=C\C3=CC=C(F)C=C3O
Biological Activity: CLP257 is a selective K+-Cl cotransporter KCC2 activator with an EC50 of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CLP257 | 99.31% | CLP257 is a selective K+-Cl cotransporter KCC2 activator with an EC50 of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
